Human Gene PDK4 (ENST00000005178.6) from GENCODE V44
Description: Homo sapiens pyruvate dehydrogenase kinase 4 (PDK4), mRNA. (from RefSeq NM_002612) RefSeq Summary (NM_002612): This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism. Expression of this gene is regulated by glucocorticoids, retinoic acid and insulin. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000005178.6 Gencode Gene: ENSG00000004799.8 Transcript (Including UTRs) Position: hg38 chr7:95,583,499-95,596,516 Size: 13,018 Total Exon Count: 11 Strand: - Coding Region Position: hg38 chr7:95,585,641-95,596,293 Size: 10,653 Coding Exon Count: 11
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q16654
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0005975 carbohydrate metabolic process GO:0006006 glucose metabolic process GO:0006468 protein phosphorylation GO:0006885 regulation of pH GO:0008286 insulin receptor signaling pathway GO:0009267 cellular response to starvation GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate GO:0010565 regulation of cellular ketone metabolic process GO:0010906 regulation of glucose metabolic process GO:0016310 phosphorylation GO:0042304 regulation of fatty acid biosynthetic process GO:0042593 glucose homeostasis GO:0042594 response to starvation GO:0045124 regulation of bone resorption GO:0046320 regulation of fatty acid oxidation GO:0071398 cellular response to fatty acid GO:0072593 reactive oxygen species metabolic process GO:2000811 negative regulation of anoikis
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