Human Gene DNAJB9 (ENST00000249356.4) from GENCODE V44
Description: Homo sapiens DnaJ heat shock protein family (Hsp40) member B9 (DNAJB9), mRNA. (from RefSeq NM_012328) RefSeq Summary (NM_012328): This gene is a member of the J protein family. J proteins function in many cellular processes by regulating the ATPase activity of 70 kDa heat shock proteins. This gene is a member of the type 2 subgroup of DnaJ proteins. The encoded protein is localized to the endoplasmic reticulum. This protein is induced by endoplasmic reticulum stress and plays a role in protecting stressed cells from apoptosis. [provided by RefSeq, Dec 2010]. Gencode Transcript: ENST00000249356.4 Gencode Gene: ENSG00000128590.5 Transcript (Including UTRs) Position: hg38 chr7:108,569,874-108,574,850 Size: 4,977 Total Exon Count: 3 Strand: + Coding Region Position: hg38 chr7:108,571,727-108,573,353 Size: 1,627 Coding Exon Count: 2
ID:DNJB9_HUMAN DESCRIPTION: RecName: Full=DnaJ homolog subfamily B member 9; AltName: Full=Microvascular endothelial differentiation gene 1 protein; Short=Mdg-1; FUNCTION: Acts as a co-chaperone with an Hsp70 protein (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note=Stress induces its translocation to the nucleus (By similarity). SIMILARITY: Contains 1 J domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UBS3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0002377 immunoglobulin production GO:0006986 response to unfolded protein GO:0030183 B cell differentiation GO:0030433 ER-associated ubiquitin-dependent protein catabolic process GO:0034976 response to endoplasmic reticulum stress GO:0036498 IRE1-mediated unfolded protein response GO:1903895 negative regulation of IRE1-mediated unfolded protein response
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