Human Gene PPP3CC (ENST00000240139.10) from GENCODE V44
Description: Homo sapiens protein phosphatase 3 catalytic subunit gamma (PPP3CC), transcript variant 2, mRNA. (from RefSeq NM_005605) RefSeq Summary (NM_001243974): Calcineurin is a calcium-dependent, calmodulin-stimulated protein phosphatase involved in the downstream regulation of dopaminergic signal transduction. Calcineurin is composed of a regulatory subunit and a catalytic subunit. The protein encoded by this gene represents one of the regulatory subunits that has been found for calcineurin. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]. Gencode Transcript: ENST00000240139.10 Gencode Gene: ENSG00000120910.15 Transcript (Including UTRs) Position: hg38 chr8:22,441,078-22,541,125 Size: 100,048 Total Exon Count: 14 Strand: + Coding Region Position: hg38 chr8:22,441,410-22,540,802 Size: 99,393 Coding Exon Count: 14
ID:PP2BC_HUMAN DESCRIPTION: RecName: Full=Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform; EC=3.1.3.16; AltName: Full=CAM-PRP catalytic subunit; AltName: Full=Calcineurin, testis-specific catalytic subunit; AltName: Full=Calmodulin-dependent calcineurin A subunit gamma isoform; FUNCTION: Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein + phosphate. COFACTOR: Binds 1 Fe(3+) ion per subunit (By similarity). COFACTOR: Binds 1 zinc ion per subunit (By similarity). SUBUNIT: Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity. TISSUE SPECIFICITY: Testis. SIMILARITY: Belongs to the PPP phosphatase family. PP-2B subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P48454
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BioCarta from NCI Cancer Genome Anatomy Project h_bcrPathway - BCR Signaling Pathway h_fcer1Pathway - Fc Epsilon Receptor I Signaling in Mast Cells h_vipPathway - Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells h_nos1Pathway - Nitric Oxide Signaling Pathway h_calcineurinPathway - Effects of calcineurin in Keratinocyte Differentiation h_gpcrPathway - Signaling Pathway from G-Protein Families h_hdacPathway - Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK) h_fMLPpathway - fMLP induced chemokine gene expression in HMC-1 cells h_nfatPathway - NFAT and Hypertrophy of the heart (Transcription in the broken heart) h_pgc1aPathway - Regulation of PGC-1a h_mef2dPathway - Role of MEF2D in T-cell Apoptosis h_ndkDynaminPathway - Endocytotic role of NDK, Phosphins and Dynamin h_tcrPathway - T Cell Receptor Signaling Pathway
Reactome (by CSHL, EBI, and GO)
Protein P48454 (Reactome details) participates in the following event(s):
US Server
