Human Gene RBPMS (ENST00000397323.9) from GENCODE V44
Description: Homo sapiens RNA binding protein, mRNA processing factor (RBPMS), transcript variant 1, mRNA. (from RefSeq NM_001008710) RefSeq Summary (NM_001008710): This gene encodes a member of the RNA recognition motif family of RNA-binding proteins. The RNA recognition motif is between 80-100 amino acids in length and family members contain one to four copies of the motif. The RNA recognition motif consists of two short stretches of conserved sequence, as well as a few highly conserved hydrophobic residues. The encoded protein has a single, putative RNA recognition motif in its N-terminus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]. Gencode Transcript: ENST00000397323.9 Gencode Gene: ENSG00000157110.16 Transcript (Including UTRs) Position: hg38 chr8:30,384,541-30,572,256 Size: 187,716 Total Exon Count: 9 Strand: + Coding Region Position: hg38 chr8:30,385,093-30,558,949 Size: 173,857 Coding Exon Count: 7
ID:RBPMS_HUMAN DESCRIPTION: RecName: Full=RNA-binding protein with multiple splicing; Short=RBP-MS; AltName: Full=Heart and RRM expressed sequence; Short=Hermes; FUNCTION: Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C- terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins. Binds to poly(A) RNA. SUBUNIT: Interacts with SMAD2, SMAD3 and SMAD4; the interactions are direct. INTERACTION: P54253:ATXN1; NbExp=3; IntAct=EBI-740322, EBI-930964; Q96PU8:QKI; NbExp=2; IntAct=EBI-740322, EBI-945792; Q53HV7:SMUG1; NbExp=2; IntAct=EBI-740322, EBI-749970; SUBCELLULAR LOCATION: Nucleus. Cytoplasm. TISSUE SPECIFICITY: Ubiquitously expressed, at various levels depending on the isoform and the tissue. DOMAIN: The RRM domain is necessary for interaction with SMAD4. Both the RRM domain and the C-terminus are required for TGFB1/Smad-mediated transactivation activity. SIMILARITY: Contains 1 RRM (RNA recognition motif) domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q93062
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000398 mRNA splicing, via spliceosome GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006396 RNA processing GO:0006979 response to oxidative stress GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0060391 positive regulation of SMAD protein import into nucleus
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