Human Gene UBE2V2 (ENST00000523111.7) from GENCODE V44
  Description: Homo sapiens ubiquitin conjugating enzyme E2 V2 (UBE2V2), mRNA. (from RefSeq NM_003350)
RefSeq Summary (NM_003350): Ubiquitin-conjugating enzyme E2 variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene also shares homology with ubiquitin-conjugating enzyme E2 variant 1 and yeast MMS2 gene product. It may be involved in the differentiation of monocytes and enterocytes. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.
Gencode Transcript: ENST00000523111.7
Gencode Gene: ENSG00000169139.12
Transcript (Including UTRs)
   Position: hg38 chr8:48,008,431-48,064,708 Size: 56,278 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg38 chr8:48,008,455-48,060,828 Size: 52,374 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:48,008,431-48,064,708)mRNA (may differ from genome)Protein (145 aa)
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neXtProtOMIMPubMedReactomeUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: UB2V2_HUMAN
DESCRIPTION: RecName: Full=Ubiquitin-conjugating enzyme E2 variant 2; AltName: Full=DDVit 1; AltName: Full=Enterocyte differentiation-associated factor 1; Short=EDAF-1; AltName: Full=Enterocyte differentiation-promoting factor 1; Short=EDPF-1; AltName: Full=MMS2 homolog; AltName: Full=Vitamin D3-inducible protein;
FUNCTION: Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.
SUBUNIT: Heterodimer with UBE2N. Binds CHFR.
INTERACTION: Q94A97:UBC35 (xeno); NbExp=3; IntAct=EBI-714329, EBI-994120; P61088:UBE2N; NbExp=3; IntAct=EBI-714329, EBI-1052908;
TISSUE SPECIFICITY: Detected in placenta, colon, liver and skin. Detected at very low levels in most tissues.
INDUCTION: Up-regulated in cultured fresh blood cells upon treatment with vitamin D3.
SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family.

-  Primer design for this transcript
 

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-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 19.53 RPKM in Brain - Frontal Cortex (BA9)
Total median expression: 385.56 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -5.3024-0.221 Picture PostScript Text
3' UTR -924.803880-0.238 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000608 - UBQ-conjugat_E2
IPR016135 - UBQ-conjugating_enzyme/RWD

Pfam Domains:
PF00179 - Ubiquitin-conjugating enzyme

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1J74 - X-ray MuPIT 1J7D - X-ray MuPIT 1ZGU - NMR MuPIT 3VON - X-ray MuPIT 4EPO - X-ray


ModBase Predicted Comparative 3D Structure on Q15819
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologGenome Browser
Gene Details    Gene Details
Gene Sorter    Gene Sorter
MGIRGDEnsembl  SGD
Protein SequenceProtein SequenceProtein Sequence  Protein Sequence
AlignmentAlignmentAlignment  Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
GO:0061630 ubiquitin protein ligase activity
GO:0061631 ubiquitin conjugating enzyme activity

Biological Process:
GO:0000209 protein polyubiquitination
GO:0000729 DNA double-strand break processing
GO:0006282 regulation of DNA repair
GO:0006301 postreplication repair
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0008283 cell proliferation
GO:0010976 positive regulation of neuron projection development
GO:0016567 protein ubiquitination
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0042275 error-free postreplication DNA repair
GO:0043524 negative regulation of neuron apoptotic process
GO:0045739 positive regulation of DNA repair
GO:0051965 positive regulation of synapse assembly
GO:0070534 protein K63-linked ubiquitination

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0031372 UBC13-MMS2 complex
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  BC016332 - Homo sapiens ubiquitin-conjugating enzyme E2 variant 2, mRNA (cDNA clone MGC:23763 IMAGE:4109228), complete cds.
BC016710 - Homo sapiens ubiquitin-conjugating enzyme E2 variant 2, mRNA (cDNA clone MGC:23762 IMAGE:4108684), complete cds.
BC007051 - Homo sapiens ubiquitin-conjugating enzyme E2 variant 2, mRNA (cDNA clone MGC:12465 IMAGE:3683051), complete cds.
AK313447 - Homo sapiens cDNA, FLJ93989, Homo sapiens ubiquitin-conjugating enzyme E2 variant 2 (UBE2V2),mRNA.
U62136 - Homo sapiens enterocyte differentiation associated factor EDAF-1 mRNA, complete cds.
BC062418 - Homo sapiens ubiquitin-conjugating enzyme E2 variant 2, mRNA (cDNA clone MGC:70688 IMAGE:6503261), complete cds.
BC028673 - Homo sapiens ubiquitin-conjugating enzyme E2 variant 2, mRNA (cDNA clone MGC:23744 IMAGE:4104992), complete cds.
AF049140 - Homo sapiens MMS2 (MMS2) mRNA, complete cds.
X98091 - H.sapiens mRNA for protein induced by vitamin D.
AK094617 - Homo sapiens cDNA FLJ37298 fis, clone BRAMY2015551, highly similar to Ubiquitin-conjugating enzyme E2.
AB528353 - Synthetic construct DNA, clone: pF1KB5213, Homo sapiens UBE2V2 gene for ubiquitin-conjugating enzyme E2 variant 2, without stop codon, in Flexi system.
CR407628 - Homo sapiens full open reading frame cDNA clone RZPDo834D042D for gene UBE2V2, ubiquitin-conjugating enzyme E2 variant 2 complete cds, without stopcodon.
DQ895721 - Synthetic construct Homo sapiens clone IMAGE:100010181; FLH186989.01L; RZPDo839C0862D ubiquitin-conjugating enzyme E2 variant 2 (UBE2V2) gene, encodes complete protein.
EU176520 - Synthetic construct Homo sapiens clone IMAGE:100011652; FLH264077.01L; RZPDo839B07257D ubiquitin-conjugating enzyme E2 variant 2 (UBE2V2) gene, encodes complete protein.
EU176662 - Synthetic construct Homo sapiens clone IMAGE:100011604; FLH263710.01L; RZPDo839B06251D ubiquitin-conjugating enzyme E2 variant 2 (UBE2V2) gene, encodes complete protein.
EU176696 - Synthetic construct Homo sapiens clone IMAGE:100011661; FLH264094.01L; RZPDo839G07257D ubiquitin-conjugating enzyme E2 variant 2 (UBE2V2) gene, encodes complete protein.
BT006744 - Homo sapiens ubiquitin-conjugating enzyme E2 variant 2 mRNA, complete cds.
DQ892507 - Synthetic construct clone IMAGE:100005137; FLH186993.01X; RZPDo839C0872D ubiquitin-conjugating enzyme E2 variant 2 (UBE2V2) gene, encodes complete protein.
KJ892348 - Synthetic construct Homo sapiens clone ccsbBroadEn_01742 UBE2V2 gene, encodes complete protein.
JD022262 - Sequence 3286 from Patent EP1572962.
JD034043 - Sequence 15067 from Patent EP1572962.
LF207317 - JP 2014500723-A/14820: Polycomb-Associated Non-Coding RNAs.
MA442894 - JP 2018138019-A/14820: Polycomb-Associated Non-Coding RNAs.
LF364625 - JP 2014500723-A/172128: Polycomb-Associated Non-Coding RNAs.
MA600202 - JP 2018138019-A/172128: Polycomb-Associated Non-Coding RNAs.
LF336077 - JP 2014500723-A/143580: Polycomb-Associated Non-Coding RNAs.
MA571654 - JP 2018138019-A/143580: Polycomb-Associated Non-Coding RNAs.
JD552484 - Sequence 533508 from Patent EP1572962.
JD042135 - Sequence 23159 from Patent EP1572962.
JD093355 - Sequence 74379 from Patent EP1572962.
JD062898 - Sequence 43922 from Patent EP1572962.
JD302833 - Sequence 283857 from Patent EP1572962.
JD095854 - Sequence 76878 from Patent EP1572962.
JD301623 - Sequence 282647 from Patent EP1572962.
JD506472 - Sequence 487496 from Patent EP1572962.
LF364627 - JP 2014500723-A/172130: Polycomb-Associated Non-Coding RNAs.
MA600204 - JP 2018138019-A/172130: Polycomb-Associated Non-Coding RNAs.
JD233885 - Sequence 214909 from Patent EP1572962.
JD298999 - Sequence 280023 from Patent EP1572962.
LF364628 - JP 2014500723-A/172131: Polycomb-Associated Non-Coding RNAs.
MA600205 - JP 2018138019-A/172131: Polycomb-Associated Non-Coding RNAs.
JD224549 - Sequence 205573 from Patent EP1572962.
JD357238 - Sequence 338262 from Patent EP1572962.
JD510040 - Sequence 491064 from Patent EP1572962.
JD370276 - Sequence 351300 from Patent EP1572962.
JD102041 - Sequence 83065 from Patent EP1572962.
JD481553 - Sequence 462577 from Patent EP1572962.
JD291734 - Sequence 272758 from Patent EP1572962.
JD446348 - Sequence 427372 from Patent EP1572962.
JD446349 - Sequence 427373 from Patent EP1572962.
AK123928 - Homo sapiens cDNA FLJ41934 fis, clone PERIC2005111.

-  Biochemical and Signaling Pathways
  BioCyc Knowledge Library
PWY-7511 - protein ubiquitination

Reactome (by CSHL, EBI, and GO)

Protein Q15819 (Reactome details) participates in the following event(s):

R-HSA-983152 Transfer of ubiquitin from E1 to E2
R-HSA-983140 Transfer of Ub from E2 to substrate and release of E2
R-HSA-5682629 HERC2 facilitates UBE2N:UBE2V2 binding to RNF8
R-HSA-5684071 RNF4 ubiquitinates MDC1
R-HSA-5693599 Association of Ku heterodimer with ends of DNA double-strand break
R-HSA-6790487 RNF111 ubiquitinates SUMOylated XPC
R-HSA-8943007 SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N
R-HSA-8943041 HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N
R-HSA-983157 Interaction of E3 with substrate and E2-Ub complex
R-HSA-5682863 RNF168 binds DNA DSBs
R-HSA-5683077 RNF8 and RNF168 ubiquitinate KDM4A,B
R-HSA-5682858 RNF8 and RNF168 ubiquitinate H2AFX
R-HSA-5693566 TP53BP1 associates with H4K20Me2 at DNA DSBs
R-HSA-5683384 UIMC1 and FAM175A bind DNA DSBs
R-HSA-5683405 PPP5C dephosphorylates TP53BP1
R-HSA-5683425 ATM phosphorylates TP53BP1 at DNA DSBs
R-HSA-5693551 Phosphorylation of BRCA1-A complex at multiple sites by ATM
R-HSA-5683385 Formation of BRCA1-A complex at DNA DSBs
R-HSA-5683735 CHEK2 is recruited to DNA DSBs
R-HSA-5683801 CHEK2 phosphorylates BRCA1
R-HSA-69891 Phosphorylation and activation of CHEK2 by ATM
R-HSA-5684052 PIAS4 SUMOylates MDC1
R-HSA-5686685 RIF1 and PAX1IP bind TP53BP1 at DNA DSBs
R-HSA-5686900 TP53BP1 recruits DCLRE1C to ATM
R-HSA-5686704 Activated ATM phosphorylates DCLRE1C
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-HSA-5693607 Processing of DNA double-strand break ends
R-HSA-5693571 Nonhomologous End-Joining (NHEJ)
R-HSA-5696395 Formation of Incision Complex in GG-NER
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins
R-HSA-983169 Class I MHC mediated antigen processing & presentation
R-HSA-5693606 DNA Double Strand Break Response
R-HSA-5693567 HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)
R-HSA-5693532 DNA Double-Strand Break Repair
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER)
R-HSA-8852135 Protein ubiquitination
R-HSA-1280218 Adaptive Immune System
R-HSA-5693538 Homology Directed Repair
R-HSA-73894 DNA Repair
R-HSA-5696398 Nucleotide Excision Repair
R-HSA-597592 Post-translational protein modification
R-HSA-168256 Immune System
R-HSA-392499 Metabolism of proteins
R-HSA-69473 G2/M DNA damage checkpoint
R-HSA-69481 G2/M Checkpoints
R-HSA-69620 Cell Cycle Checkpoints
R-HSA-1640170 Cell Cycle

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000523111.1, ENST00000523111.2, ENST00000523111.3, ENST00000523111.4, ENST00000523111.5, ENST00000523111.6, MMS2, NM_003350, Q15819, UB2V2_HUMAN, uc003xqm.1, uc003xqm.2, uc003xqm.3, uc003xqm.4, uc003xqm.5, UEV2
UCSC ID: ENST00000523111.7
RefSeq Accession: NM_003350
Protein: Q15819 (aka UB2V2_HUMAN or U2V2_HUMAN)
CCDS: CCDS43738.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.