Human Gene CCN4 (ENST00000250160.11) from GENCODE V44
Description: Homo sapiens cellular communication network factor 4 (CCN4), transcript variant 1, mRNA. (from RefSeq NM_003882) RefSeq Summary (NM_003882): This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2011]. Gencode Transcript: ENST00000250160.11 Gencode Gene: ENSG00000104415.14 Transcript (Including UTRs) Position: hg38 chr8:133,191,039-133,231,690 Size: 40,652 Total Exon Count: 5 Strand: + Coding Region Position: hg38 chr8:133,191,145-133,227,710 Size: 36,566 Coding Exon Count: 5
ID:WISP1_HUMAN DESCRIPTION: RecName: Full=WNT1-inducible-signaling pathway protein 1; Short=WISP-1; AltName: Full=CCN family member 4; AltName: Full=Wnt-1-induced secreted protein; Flags: Precursor; FUNCTION: Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Expressed in heart, kidney, lung, pancreas, placenta, ovary, small intestine and spleen. Isoform 2 is expressed predominantly in scirrhous gastric carcinoma and, weakly in placenta. Overexpression is associated with several cancers including breast cancer and colon tumors. Isoform 2 is overexpressed in scirrhous gastric carcinoma. SIMILARITY: Belongs to the CCN family. SIMILARITY: Contains 1 CTCK (C-terminal cystine knot-like) domain. SIMILARITY: Contains 1 IGFBP N-terminal domain. SIMILARITY: Contains 1 TSP type-1 domain. SIMILARITY: Contains 1 VWFC domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00007 - Cystine-knot domain PF00219 - Insulin-like growth factor binding protein PF00090 - Thrombospondin type 1 domain PF00093 - von Willebrand factor type C domain
ModBase Predicted Comparative 3D Structure on O95388
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
