Human Gene IARS1 (ENST00000375643.7) from GENCODE V44
Description: Homo sapiens isoleucyl-tRNA synthetase 1 (IARS1), transcript variant 2, mRNA. (from RefSeq NM_013417) RefSeq Summary (NM_013417): Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis. Alternatively spliced transcript variants have been found. [provided by RefSeq, Nov 2012]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Gencode Transcript: ENST00000375643.7 Gencode Gene: ENSG00000196305.19 Transcript (Including UTRs) Position: hg38 chr9:92,210,207-92,293,700 Size: 83,494 Total Exon Count: 34 Strand: - Coding Region Position: hg38 chr9:92,210,807-92,289,419 Size: 78,613 Coding Exon Count: 33
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF08264 - Anticodon-binding domain of tRNA PF00133 - tRNA synthetases class I (I, L, M and V)
ModBase Predicted Comparative 3D Structure on P41252
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
