Human Gene GABRE (ENST00000370328.4) from GENCODE V44
Description: Homo sapiens gamma-aminobutyric acid type A receptor subunit epsilon (GABRE), mRNA. (from RefSeq NM_004961) RefSeq Summary (NM_004961): The product of this gene belongs to the ligand-gated ionic channel (TC 1.A.9) family. It encodes the gamma-aminobutyric acid (GABA) A receptor which is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes an epsilon subunit. It is mapped to chromosome Xq28 in a cluster comprised of genes encoding alpha 3, beta 4 and theta subunits of the same receptor. Alternatively spliced transcript variants have been identified, but only one is thought to encode a protein. [provided by RefSeq, Oct 2008]. Gencode Transcript: ENST00000370328.4 Gencode Gene: ENSG00000102287.19 Transcript (Including UTRs) Position: hg38 chrX:151,953,124-151,974,676 Size: 21,553 Total Exon Count: 9 Strand: - Coding Region Position: hg38 chrX:151,954,701-151,974,625 Size: 19,925 Coding Exon Count: 9
ID:GBRE_HUMAN DESCRIPTION: RecName: Full=Gamma-aminobutyric acid receptor subunit epsilon; AltName: Full=GABA(A) receptor subunit epsilon; Flags: Precursor; FUNCTION: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. SUBUNIT: Generally pentameric. Associates with alpha and beta subunits. SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in many tissues. Highest levels of expression in adult heart and placenta. SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRE sub-subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P78334
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006811 ion transport GO:0006821 chloride transport GO:0007165 signal transduction GO:0034220 ion transmembrane transport GO:1902476 chloride transmembrane transport GO:2001226 negative regulation of chloride transport
US Server
