Human Gene GRM2 (ENST00000395052.8) from GENCODE V44
Description: Homo sapiens glutamate metabotropic receptor 2 (GRM2), transcript variant 4, mRNA. (from RefSeq NM_001349117) RefSeq Summary (NM_000839): L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2017]. Gencode Transcript: ENST00000395052.8 Gencode Gene: ENSG00000164082.15 Transcript (Including UTRs) Position: hg38 chr3:51,707,068-51,718,613 Size: 11,546 Total Exon Count: 6 Strand: + Coding Region Position: hg38 chr3:51,708,984-51,718,112 Size: 9,129 Coding Exon Count: 5
ID:GRM2_HUMAN DESCRIPTION: RecName: Full=Metabotropic glutamate receptor 2; Short=mGluR2; Flags: Precursor; FUNCTION: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization. SUBUNIT: Interacts with GRASP (By similarity). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Widely expressed in different regions of the adult brain as well as in fetal brain. SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00003 - 7 transmembrane sweet-taste receptor of 3 GCPR PF01094 - Receptor family ligand binding region PF07562 - Nine Cysteines Domain of family 3 GPCR
ModBase Predicted Comparative 3D Structure on Q14416
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
