Human Gene TRAF1 (ENST00000540010.1) from GENCODE V44
Description: Homo sapiens TNF receptor associated factor 1 (TRAF1), transcript variant 2, mRNA. (from RefSeq NM_001190945) RefSeq Summary (NM_001190945): The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]. Gencode Transcript: ENST00000540010.1 Gencode Gene: ENSG00000056558.11 Transcript (Including UTRs) Position: hg38 chr9:120,902,393-120,929,173 Size: 26,781 Total Exon Count: 9 Strand: - Coding Region Position: hg38 chr9:120,905,020-120,926,075 Size: 21,056 Coding Exon Count: 7
ID:TRAF1_HUMAN DESCRIPTION: RecName: Full=TNF receptor-associated factor 1; AltName: Full=Epstein-Barr virus-induced protein 6; FUNCTION: Adapter molecule that regulates the activation of NF- kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein- ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2. SUBUNIT: Homotrimer. Heterotrimer with TRAF2. Interacts with TNFRSF1A/TNFR1, TNFRSF1B/TNFR2, TNFRSF4, TNFRSF5/CD40, TNFRSF8/CD30, TNFRSF9/CD137, TNFRSF11A/RANK, TNFRSF13C, TNFRSF18/AITR, TNFRSF17/BCMA, TNFRSF19/TROY, TNFRSF19L/RELT, XEDAR, EDAR, Epstein-Barr virus BNFL1/LMP-1, TANK/ITRAF, TRAIP and RIPK2. Interacts with BIRC2 and BIRC3 N-terminus; a single BIRC2 or BIRC3 molecule interacts with a heterotrimer formed by TRAF1 and TRAF2. Interacts with NFATC2IP, TRAFD1 and with HIVEP3 (By similarity). Interacts with MAP3K14. INTERACTION: Q14161:GIT2; NbExp=2; IntAct=EBI-359224, EBI-1046878; DOMAIN: The coiled coil domain mediates homo- and hetero- oligomerization. DOMAIN: The MATH/TRAF domain binds to receptor cytoplasmic domains. DOMAIN: Cleavage by CASP8 liberates a C-terminal fragment that promotes apoptosis and inhibits the activation of NF-kappa-B in response to TNF signaling. PTM: Polyubiquitinated by BIRC2 and/or BIRC3, leading to its subsequent proteasomal degradation. SIMILARITY: Contains 1 MATH domain. CAUTION: Lacks a RING domain and has therefore no E3 ubiquitin- protein ligase activity by itself. SEQUENCE CAUTION: Sequence=BAC03449.1; Type=Frameshift; Positions=111;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q13077
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
