Human Gene AIFM2 (ENST00000373248.5) from GENCODE V44
Description: Oxidoreductase, which may play a role in mediating a p53/TP53-dependent apoptosis response. Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death. Binds to DNA in a sequence-independent manner. May contribute to genotoxin-induced growth arrest. (from UniProt Q9BRQ8) RefSeq Summary (NM_001198696): This gene encodes a flavoprotein oxidoreductase that binds single stranded DNA and is thought to contribute to apoptosis in the presence of bacterial and viral DNA. The expression of this gene is also found to be induced by tumor suppressor protein p53 in colon cancer cells. [provided by RefSeq, Nov 2010]. Gencode Transcript: ENST00000373248.5 Gencode Gene: ENSG00000042286.15 Transcript (Including UTRs) Position: hg38 chr10:70,098,223-70,124,102 Size: 25,880 Total Exon Count: 9 Strand: - Coding Region Position: hg38 chr10:70,114,178-70,124,084 Size: 9,907 Coding Exon Count: 8
ID:AIFM2_HUMAN DESCRIPTION: RecName: Full=Apoptosis-inducing factor 2; EC=1.-.-.-; AltName: Full=Apoptosis-inducing factor homologous mitochondrion-associated inducer of death; AltName: Full=Apoptosis-inducing factor-like mitochondrion-associated inducer of death; AltName: Full=p53-responsive gene 3 protein; FUNCTION: Oxidoreductase, which may play a role in mediating a p53/TP53-dependent apoptosis response. Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death. Binds to DNA in a sequence-independent manner. May contribute to genotoxin-induced growth arrest. COFACTOR: FAD. Binds 6-hydroxy-FAD non-covalently. SUBCELLULAR LOCATION: Cytoplasm. Mitochondrion outer membrane. TISSUE SPECIFICITY: Detected in most normal tissues as two transcripts of 1.8 and 4.0 kb in length, respectively. Highly expressed in heart, moderately in liver and skeletal muscles, and expressed at low levels in placenta, lung, kidney, and pancreas. Both transcripts expressed following p53/TP53 induction. The shorter 1.8 kb transcript seems to be the major transcript in EB1 colon cancer cells. INDUCTION: Expression detected at 4 hours after induction by p53/TP53. Down-regulated in a wide range of human tumors. SIMILARITY: Belongs to the FAD-dependent oxidoreductase family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BRQ8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006915 apoptotic process GO:0008637 apoptotic mitochondrial changes GO:0022904 respiratory electron transport chain GO:0042981 regulation of apoptotic process GO:0043065 positive regulation of apoptotic process GO:0055114 oxidation-reduction process