Human Gene MOGAT2 (ENST00000198801.10) from GENCODE V44
Description: Homo sapiens monoacylglycerol O-acyltransferase 2 (MOGAT2), mRNA. (from RefSeq NM_025098) RefSeq Summary (NM_025098): The protein encoded by this gene is an enzyme that catalyzes the synthesis of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. The encoded protein is important in the uptake of dietary fat by the small intestine. This protein forms a complex with diacylglycerol O-acyltransferase 2 in the endoplasmic reticulum, and this complex catalyzes the synthesis of triacylglycerol. [provided by RefSeq, Dec 2015]. Gencode Transcript: ENST00000198801.10 Gencode Gene: ENSG00000166391.15 Transcript (Including UTRs) Position: hg38 chr11:75,717,838-75,732,953 Size: 15,116 Total Exon Count: 6 Strand: + Coding Region Position: hg38 chr11:75,717,889-75,731,286 Size: 13,398 Coding Exon Count: 6
ID:MOGT2_HUMAN DESCRIPTION: RecName: Full=2-acylglycerol O-acyltransferase 2; EC=2.3.1.22; AltName: Full=Acyl-CoA:monoacylglycerol acyltransferase 2; Short=MGAT2; Short=hMGAT2; AltName: Full=Diacylglycerol O-acyltransferase candidate 5; Short=hDC5; AltName: Full=Diacylglycerol acyltransferase 2-like protein 5; AltName: Full=Monoacylglycerol O-acyltransferase 2; FUNCTION: Catalyzes the formation of diacylglycerol from 2- monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity. CATALYTIC ACTIVITY: Acyl-CoA + 2-acylglycerol = CoA + diacylglycerol. ENZYME REGULATION: Inhibited by oleic acid and sphingosine, while it is stimulated by phosphatidylcholine, phosphatidylserine and phosphatidic acid (By similarity). BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=45 uM for sn-1-monooleoylglycerol; PATHWAY: Glycerolipid metabolism; triacylglycerol biosynthesis. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Highly expressed in liver, small intestine, colon, stomach and kidney. SIMILARITY: Belongs to the diacylglycerol acyltransferase family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q3SYC2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.