Human Gene VN1R4 (ENST00000311170.5) from GENCODE V44
  Description: Homo sapiens vomeronasal 1 receptor 4 (VN1R4), mRNA. (from RefSeq NM_173857)
Gencode Transcript: ENST00000311170.5
Gencode Gene: ENSG00000228567.3
Transcript (Including UTRs)
   Position: hg38 chr19:53,266,676-53,267,723 Size: 1,048 Total Exon Count: 1 Strand: -
Coding Region
   Position: hg38 chr19:53,266,760-53,267,665 Size: 906 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:53,266,676-53,267,723)mRNA (may differ from genome)Protein (301 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGencodeGeneCardsHGNC
HPRDLynxMalacardsMGIneXtProtPubMed
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: VN1R4_HUMAN
DESCRIPTION: RecName: Full=Vomeronasal type-1 receptor 4; AltName: Full=G-protein coupled receptor GPCR27; Short=hGPCR27; AltName: Full=V1r-like receptor 4;
FUNCTION: Putative pheromone receptor.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
POLYMORPHISM: Various VN1R4 alleles are known. The sequence shown is that of allele VN1R4*1.
MISCELLANEOUS: The chimpanzee and gorilla orthologous proteins do not exist, their genes are pseudogenes.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
WEB RESOURCE: Name=Protein Spotlight; Note=No one nose - Issue 61 of August 2005; URL="http://web.expasy.org/spotlight/back_issues/sptlt061.shtml";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.24 RPKM in Testis
Total median expression: 0.24 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -9.4058-0.162 Picture PostScript Text
3' UTR -8.7084-0.104 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR017452 - GPCR_Rhodpsn_supfam
IPR004072 - Vmron_rcpt_1

Pfam Domains:
PF03402 - Vomeronasal organ pheromone receptor family, V1R

ModBase Predicted Comparative 3D Structure on Q7Z5H5
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0016503 pheromone receptor activity

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007606 sensory perception of chemical stimulus
GO:0019236 response to pheromone

Cellular Component:
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC104935 - Homo sapiens vomeronasal 1 receptor 4, mRNA (cDNA clone MGC:132595 IMAGE:8143938), complete cds.
BC104939 - Homo sapiens vomeronasal 1 receptor 4, mRNA (cDNA clone MGC:132599 IMAGE:8143942), complete cds.
LP895385 - Sequence 249 from Patent EP3253886.
KJ900599 - Synthetic construct Homo sapiens clone ccsbBroadEn_09993 VN1R4 gene, encodes complete protein.
AB529267 - Synthetic construct DNA, clone: pF1KE0844, Homo sapiens VN1R4 gene for vomeronasal 1 receptor 4, without stop codon, in Flexi system.
JD137242 - Sequence 118266 from Patent EP1572962.
JD060847 - Sequence 41871 from Patent EP1572962.
JD504745 - Sequence 485769 from Patent EP1572962.
JD478659 - Sequence 459683 from Patent EP1572962.
JD302818 - Sequence 283842 from Patent EP1572962.
JD074354 - Sequence 55378 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000311170.1, ENST00000311170.2, ENST00000311170.3, ENST00000311170.4, NM_173857, Q2M3E2, Q7Z5H5, Q7Z5H6, Q7Z5H7, Q8TDU2, uc010ydu.1, uc010ydu.2, uc010ydu.3, V1RL4, VN1R4_HUMAN
UCSC ID: ENST00000311170.5
RefSeq Accession: NM_173857
Protein: Q7Z5H5 (aka VN1R4_HUMAN)
CCDS: CCDS33099.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.