Human Gene TAAR6 (ENST00000275198.1) from GENCODE V44
  Description: Homo sapiens trace amine associated receptor 6 (TAAR6), mRNA. (from RefSeq NM_175067)
RefSeq Summary (NM_175067): This gene encodes a seven-transmembrane G-protein-coupled receptor that likely functions as a receptor for endogenous trace amines. Mutations in this gene may be associated with schizophrenia.[provided by RefSeq, Feb 2010].
Gencode Transcript: ENST00000275198.1
Gencode Gene: ENSG00000146383.7
Transcript (Including UTRs)
   Position: hg38 chr6:132,570,322-132,571,359 Size: 1,038 Total Exon Count: 1 Strand: +
Coding Region
   Position: hg38 chr6:132,570,322-132,571,359 Size: 1,038 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:132,570,322-132,571,359)mRNA (may differ from genome)Protein (345 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
OMIMPubMedReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TAAR6_HUMAN
DESCRIPTION: RecName: Full=Trace amine-associated receptor 6; Short=TaR-6; Short=Trace amine receptor 6; AltName: Full=Trace amine receptor 4; Short=TaR-4;
FUNCTION: Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Expressed at low abundance in various brain tissues, as well as in fetal liver, but not in the cerebellum or placenta. In the brain, comparable levels of expression in basal ganglia, frontal cortex, substantia nigra, amygdala and hippocampus, highest expression in hippocampus and lowest expression in basal ganglia.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.

-  Primer design for this transcript
 

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-  MalaCards Disease Associations
  MalaCards Gene Search: TAAR6
Diseases sorted by gene-association score: schizophrenia* (41), cyclosporiasis (4)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.05 RPKM in Kidney - Cortex
Total median expression: 0.05 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR009132 - Trace_amine_rcpt

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

ModBase Predicted Comparative 3D Structure on Q96RI8
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
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Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0001594 trace-amine receptor activity
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway

Cellular Component:
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AB529264 - Synthetic construct DNA, clone: pF1KE0840, Homo sapiens TAAR6 gene for trace amine associated receptor 6, without stop codon, in Flexi system.
AY183470 - Homo sapiens trace amine receptor 4 mRNA, complete cds.
BC069157 - Homo sapiens trace amine associated receptor 6, mRNA (cDNA clone MGC:95443 IMAGE:7217018), complete cds.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04080 - Neuroactive ligand-receptor interaction

Reactome (by CSHL, EBI, and GO)

Protein Q96RI8 (Reactome details) participates in the following event(s):

R-HSA-391211 Trace amine-associated receptors can bind trace amines
R-HSA-744886 The Ligand:GPCR:Gs complex dissociates
R-HSA-744887 Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs
R-HSA-379044 Liganded Gs-activating GPCR acts as a GEF for Gs
R-HSA-375280 Amine ligand-binding receptors
R-HSA-418555 G alpha (s) signalling events
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-388396 GPCR downstream signalling
R-HSA-500792 GPCR ligand binding
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: NM_175067, Q5VUQ4, Q96RI8, TA4, TAAR6_HUMAN, TAR4, TRAR4, uc011eck.1, uc011eck.2
UCSC ID: ENST00000275198.1
RefSeq Accession: NM_175067
Protein: Q96RI8 (aka TAAR6_HUMAN)
CCDS: CCDS5155.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.