Human Gene TAAR6 (ENST00000275198.1) from GENCODE V44
Description: Homo sapiens trace amine associated receptor 6 (TAAR6), mRNA. (from RefSeq NM_175067) RefSeq Summary (NM_175067): This gene encodes a seven-transmembrane G-protein-coupled receptor that likely functions as a receptor for endogenous trace amines. Mutations in this gene may be associated with schizophrenia.[provided by RefSeq, Feb 2010]. Gencode Transcript: ENST00000275198.1 Gencode Gene: ENSG00000146383.7 Transcript (Including UTRs) Position: hg38 chr6:132,570,322-132,571,359 Size: 1,038 Total Exon Count: 1 Strand: + Coding Region Position: hg38 chr6:132,570,322-132,571,359 Size: 1,038 Coding Exon Count: 1
ID:TAAR6_HUMAN DESCRIPTION: RecName: Full=Trace amine-associated receptor 6; Short=TaR-6; Short=Trace amine receptor 6; AltName: Full=Trace amine receptor 4; Short=TaR-4; FUNCTION: Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed at low abundance in various brain tissues, as well as in fetal liver, but not in the cerebellum or placenta. In the brain, comparable levels of expression in basal ganglia, frontal cortex, substantia nigra, amygdala and hippocampus, highest expression in hippocampus and lowest expression in basal ganglia. SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
ModBase Predicted Comparative 3D Structure on Q96RI8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.