Human Gene TAS2R40 (ENST00000408947.4) from GENCODE V44
Description: Homo sapiens taste 2 receptor member 40 (TAS2R40), mRNA. (from RefSeq NM_176882) RefSeq Summary (NM_176882): This gene encodes a member of the bitter taste receptor family which belong to the G protein-coupled receptor superfamily and are predominantly expressed in taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a seven-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered together with eight other taste receptor genes on chromosome 7. A decrease in the expression of this gene is associated with hypogeusia. [provided by RefSeq, Jul 2017]. ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000408947.4/ ENSP00000386210.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Gencode Transcript: ENST00000408947.4 Gencode Gene: ENSG00000221937.4 Transcript (Including UTRs) Position: hg38 chr7:143,222,037-143,223,079 Size: 1,043 Total Exon Count: 1 Strand: + Coding Region Position: hg38 chr7:143,222,079-143,223,050 Size: 972 Coding Exon Count: 1
ID:T2R40_HUMAN DESCRIPTION: RecName: Full=Taste receptor type 2 member 40; Short=T2R40; AltName: Full=G-protein coupled receptor 60; AltName: Full=Taste receptor type 2 member 58; Short=T2R58; FUNCTION: Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells. MISCELLANEOUS: Several bitter taste receptors are expressed in a single taste receptor cell. SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF05296 - Taste receptor protein (TAS2R)
ModBase Predicted Comparative 3D Structure on P59535
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste GO:0007165 signal transduction GO:0007186 G-protein coupled receptor signaling pathway GO:0050896 response to stimulus GO:0050909 sensory perception of taste