Human Gene MOS (ENST00000311923.1) from GENCODE V44
  Description: Homo sapiens MOS proto-oncogene, serine/threonine kinase (MOS), mRNA. (from RefSeq NM_005372)
RefSeq Summary (NM_005372): MOS is a serine/threonine kinase that activates the MAP kinase cascade through direct phosphorylation of the MAP kinase activator MEK (MAP2K1; MIM 176872) (Prasad et al., 2008 [PubMed 18246541]).[supplied by OMIM, Jul 2009].
Gencode Transcript: ENST00000311923.1
Gencode Gene: ENSG00000172680.1
Transcript (Including UTRs)
   Position: hg38 chr8:56,112,942-56,113,982 Size: 1,041 Total Exon Count: 1 Strand: -
Coding Region
   Position: hg38 chr8:56,112,942-56,113,982 Size: 1,041 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:56,112,942-56,113,982)mRNA (may differ from genome)Protein (346 aa)
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-  Comments and Description Text from UniProtKB
  ID: MOS_HUMAN
DESCRIPTION: RecName: Full=Proto-oncogene serine/threonine-protein kinase mos; EC=2.7.11.1; AltName: Full=Oocyte maturation factor mos; AltName: Full=Proto-oncogene c-Mos;
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
TISSUE SPECIFICITY: Expressed specifically in testis during spermatogenesis.
SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
SIMILARITY: Contains 1 protein kinase domain.

-  Primer design for this transcript
 

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Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: MOS
Diseases sorted by gene-association score: sarcoma (10)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.81 RPKM in Testis
Total median expression: 1.05 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR008271 - Ser/Thr_kinase_AS

Pfam Domains:
PF00069 - Protein kinase domain

ModBase Predicted Comparative 3D Structure on P00540
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsemblEnsembl  
Protein SequenceProtein SequenceProtein SequenceProtein Sequence  
AlignmentAlignmentAlignmentAlignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity

Biological Process:
GO:0000165 MAPK cascade
GO:0000186 activation of MAPKK activity
GO:0000187 activation of MAPK activity
GO:0000212 meiotic spindle organization
GO:0006325 chromatin organization
GO:0006468 protein phosphorylation
GO:0016310 phosphorylation
GO:0035556 intracellular signal transduction
GO:0043410 positive regulation of MAPK cascade
GO:0046777 protein autophosphorylation
GO:0051296 establishment of meiotic spindle orientation
GO:1902103 negative regulation of metaphase/anaphase transition of meiotic cell cycle

Cellular Component:
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  BC069569 - Homo sapiens v-mos Moloney murine sarcoma viral oncogene homolog, mRNA (cDNA clone MGC:97024 IMAGE:7262233), complete cds.
BC106737 - Homo sapiens v-mos Moloney murine sarcoma viral oncogene homolog, mRNA (cDNA clone MGC:119962 IMAGE:40016104), complete cds.
BC106738 - Homo sapiens v-mos Moloney murine sarcoma viral oncogene homolog, mRNA (cDNA clone MGC:119963 IMAGE:40016106), complete cds.
BC069590 - Homo sapiens v-mos Moloney murine sarcoma viral oncogene homolog, mRNA (cDNA clone IMAGE:7262245), partial cds.
HQ447500 - Synthetic construct Homo sapiens clone IMAGE:100070836; CCSB013876_01 v-mos Moloney murine sarcoma viral oncogene homolog (MOS) gene, encodes complete protein.
KJ891635 - Synthetic construct Homo sapiens clone ccsbBroadEn_01029 MOS gene, encodes complete protein.
KJ905228 - Synthetic construct Homo sapiens clone ccsbBroadEn_14699 MOS gene, encodes complete protein.
AB464742 - Synthetic construct DNA, clone: pF1KB9834, Homo sapiens MOS gene for v-mos Moloney murine sarcoma viral oncogene homolog, without stop codon, in Flexi system.
AY279177 - Homo sapiens oncogene MOS-like gene, partial sequence.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04010 - MAPK signaling pathway
hsa04114 - Oocyte meiosis
hsa04810 - Regulation of actin cytoskeleton
hsa04914 - Progesterone-mediated oocyte maturation

-  Other Names for This Gene
  Alternate Gene Symbols: MOS_HUMAN, NM_005372, P00540, Q3KPG9, Q3KPH0, uc011leb.1, uc011leb.2
UCSC ID: ENST00000311923.1
RefSeq Accession: NM_005372
Protein: P00540 (aka MOS_HUMAN)
CCDS: CCDS6164.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.