Human Gene ARMCX4 (ENST00000423738.5) from GENCODE V44
  Description: Homo sapiens armadillo repeat containing X-linked 4 (ARMCX4), transcript variant 1, mRNA. (from RefSeq NM_001256155)
RefSeq Summary (NM_001256155): The product of this gene belongs to the armadillo repeat-containing family of proteins, which interact with other proteins in a variety of cellular processes. The function of this family member is currently unknown. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012].
Gencode Transcript: ENST00000423738.5
Gencode Gene: ENSG00000196440.12
Transcript (Including UTRs)
   Position: hg38 chrX:101,485,456-101,495,807 Size: 10,352 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg38 chrX:101,488,590-101,495,462 Size: 6,873 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:101,485,456-101,495,807)mRNA (may differ from genome)Protein (2290 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGencodeGeneCardsHGNC
HPRDMGIneXtProtOMIMPubMedUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ARMX4_HUMAN
DESCRIPTION: RecName: Full=Armadillo repeat-containing X-linked protein 4;
SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential).

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 9.19 RPKM in Ovary
Total median expression: 140.06 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -181.30511-0.355 Picture PostScript Text
3' UTR -72.20345-0.209 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on Q5H9R4
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGI     
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  CR933662 - Homo sapiens mRNA; cDNA DKFZp781M0415 (from clone DKFZp781M0415).
BC036206 - Homo sapiens armadillo repeat containing, X-linked 4, mRNA (cDNA clone IMAGE:5261888).
AK292543 - Homo sapiens cDNA FLJ77781 complete cds, highly similar to Homo sapiens armadillo repeat containing, X-linked 4 (ARMCX4), mRNA.
AK126987 - Homo sapiens cDNA FLJ45041 fis, clone BRAWH3020884, highly similar to Armadillo repeat-containing X-linked protein 4.
AK096955 - Homo sapiens cDNA FLJ39636 fis, clone SMINT2002976.
AK125041 - Homo sapiens cDNA FLJ43051 fis, clone BRTHA3005735.
BC032236 - Homo sapiens armadillo repeat containing, X-linked 4, mRNA (cDNA clone IMAGE:5246921).
JD551085 - Sequence 532109 from Patent EP1572962.
JD078840 - Sequence 59864 from Patent EP1572962.
JD239662 - Sequence 220686 from Patent EP1572962.
JD309427 - Sequence 290451 from Patent EP1572962.
KJ904357 - Synthetic construct Homo sapiens clone ccsbBroadEn_13751 ARMCX4 gene, encodes complete protein.
DQ581735 - Homo sapiens piRNA piR-49847, complete sequence.
AY726601 - Homo sapiens clone MO-32 mRNA sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K928, ARMX4_HUMAN, B3KXA4, ENST00000423738.1, ENST00000423738.2, ENST00000423738.3, ENST00000423738.4, NM_001256155, Q5H9K8, Q5H9R4, Q8N8D6, uc031tkc.1, uc031tkc.2
UCSC ID: ENST00000423738.5
RefSeq Accession: NM_001256155
Protein: Q5H9R4 (aka ARMX4_HUMAN)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.