Human Gene PEAR1 (ENST00000338302.7) from GENCODE V44
Description: Homo sapiens platelet endothelial aggregation receptor 1 (PEAR1), transcript variant 3, mRNA. (from RefSeq NM_001353683) RefSeq Summary (NM_001353683): PEAR1 is a platelet receptor that signals upon the formation of platelet-platelet contacts independent of platelet activation and secondary to platelet aggregation (Nanda et al., 2005 [PubMed 15851471]).[supplied by OMIM, Mar 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Gencode Transcript: ENST00000338302.7 Gencode Gene: ENSG00000187800.14 Transcript (Including UTRs) Position: hg38 chr1:156,893,720-156,916,429 Size: 22,710 Total Exon Count: 24 Strand: + Coding Region Position: hg38 chr1:156,903,927-156,914,798 Size: 10,872 Coding Exon Count: 22
ID:PEAR1_HUMAN DESCRIPTION: RecName: Full=Platelet endothelial aggregation receptor 1; Short=hPEAR1; AltName: Full=Multiple epidermal growth factor-like domains protein 12; Short=Multiple EGF-like domains protein 12; Flags: Precursor; FUNCTION: When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells (By similarity). SUBUNIT: Interacts with SHC2 upon its aggregation-induced tyrosine phosphorylation. SUBCELLULAR LOCATION: Cell membrane; Single-pass membrane protein (Potential). Note=Detected on the cell surface in resting platelets. TISSUE SPECIFICITY: Expressed in umbilical vein endothelial cells and platelets (at protein level). Expressed in heart, kidney, skeletal muscle, pancreas, ovary, breast, lung, brain cortex, hypothalamus, spinal cord, dorsal root ganglion, endothelial cells of umbilical cord artery and vein, megakaryocytes, osteoblasts, coronary muscle and erythroid cells. Weakly expressed in peripheral blood leukocytes and macrophages. PTM: Phosphorylated in the intracellular domain on tyrosine residues (By similarity). Phosphorylated on tyrosine residues by SRC. Tyrosine phosphorylation is detected upon platelet aggregation stimulated by collagen, TRAP and thrombin and platelet-platelet contacts but not after platelet activation. Tyrosine phosphorylation enhanced its association with SHC1 and SHC2. SIMILARITY: Belongs to the MEGF family. SIMILARITY: Contains 9 EGF-like domains. SIMILARITY: Contains 1 EMI domain. SEQUENCE CAUTION: Sequence=BAB84947.1; Type=Frameshift; Positions=557;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q5VY43
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
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Sequence and Links to Tools and Databases 
Microarray Expression Data 
