Human Gene KANSL1 (ENST00000572904.6) from GENCODE V44
Description: Homo sapiens KAT8 regulatory NSL complex subunit 1 (KANSL1), transcript variant 4, mRNA. (from RefSeq NM_001379198) RefSeq Summary (NM_001379198): This gene encodes a nuclear protein that is a subunit of two protein complexes involved with histone acetylation, the MLL1 complex and the NSL1 complex. The corresponding protein in Drosophila interacts with K(lysine) acetyltransferase 8, which is also a subunit of both the MLL1 and NSL1 complexes. [provided by RefSeq, Jun 2012]. Gencode Transcript: ENST00000572904.6 Gencode Gene: ENSG00000120071.15 Transcript (Including UTRs) Position: hg38 chr17:46,029,916-46,223,676 Size: 193,761 Total Exon Count: 15 Strand: - Coding Region Position: hg38 chr17:46,031,476-46,172,143 Size: 140,668 Coding Exon Count: 14
ID:KANL1_HUMAN DESCRIPTION: RecName: Full=KAT8 regulatory NSL complex subunit 1; AltName: Full=MLL1/MLL complex subunit KANSL1; AltName: Full=MSL1 homolog 1; Short=hMSL1v1; AltName: Full=NSL complex protein NSL1; AltName: Full=Non-specific lethal 1 homolog; FUNCTION: As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription. SUBUNIT: Component of some MLL1/MLL complex, at least composed of the core components MLL, ASH2L, HCFC1, WDR5 and RBBP5, as well as the facultative components C17orf49, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1. Interacts with KAT8; the interaction is direct. INTERACTION: Q15834:CCDC85B; NbExp=2; IntAct=EBI-740244, EBI-739674; SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Expressed in the brain. SEQUENCE CAUTION: Sequence=CAH10565.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q7Z3B3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.