Human Gene DDX17 (ENST00000403230.3) from GENCODE V44
Description: Homo sapiens DEAD-box helicase 17 (DDX17), transcript variant 1, mRNA. (from RefSeq NM_006386) RefSeq Summary (NM_006386): DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and splicesosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an ATPase activated by a variety of RNA species, but not by dsDNA. This protein, and that encoded by DDX5 gene, are more closely related to each other than to any other member of the DEAD box family. This gene can encode multiple isoforms due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) start codon. [provided by RefSeq, Apr 2011]. Gencode Transcript: ENST00000403230.3 Gencode Gene: ENSG00000100201.23 Transcript (Including UTRs) Position: hg38 chr22:38,483,438-38,506,311 Size: 22,874 Total Exon Count: 13 Strand: - Coding Region Position: hg38 chr22:38,485,935-38,506,237 Size: 20,303 Coding Exon Count: 13
ID:DDX17_HUMAN DESCRIPTION: RecName: Full=Probable ATP-dependent RNA helicase DDX17; EC=3.6.4.13; AltName: Full=DEAD box protein 17; AltName: Full=DEAD box protein p72; AltName: Full=RNA-dependent helicase p72; FUNCTION: RNA-dependent ATPase activity. Involved in transcriptional regulation. Transcriptional coactivator for estrogen receptor ESR1. Increases ESR1 AF-1 domain-mediated transactivation. Synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and probably involved in skeletal muscle differentiation. Required for zinc-finger antiviral protein ZC3HAV1-mediated mRNA degradation. CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate. SUBUNIT: Interacts with ESR1. Interacts with NCOA1, NCOA2, NCOA3, TP53 and HDAC1. Self-associates. Interacts with DDX5. Interacts with DCP1A in an RNA-independent manner. Interacts with DCP2 in an RNA-dependent manner. Interacts with ZC3HAV1 (via N-terminal domain) in an RNA-independent manner. Interacts with EXOSC3 and EXOSC5 only in the presence of ZC3HAV1 in an RNA-independent manner. INTERACTION: P03372:ESR1; NbExp=7; IntAct=EBI-746012, EBI-78473; Q13547:HDAC1; NbExp=3; IntAct=EBI-5280703, EBI-301834; Q15596:NCOA2; NbExp=2; IntAct=EBI-746012, EBI-81236; Q9Y6Q9:NCOA3; NbExp=2; IntAct=EBI-746012, EBI-81196; P04637:TP53; NbExp=3; IntAct=EBI-746012, EBI-366083; SUBCELLULAR LOCATION: Nucleus. Nucleus, nucleolus. TISSUE SPECIFICITY: Ubiquitous. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. PTM: Sumoylation significantly increases stability, it also promotes interaction with HDAC1. SIMILARITY: Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily. SIMILARITY: Contains 1 helicase ATP-binding domain. SIMILARITY: Contains 1 helicase C-terminal domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q92841
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
