Human Gene C3orf33 (ENST00000534941.2) from GENCODE V44
  Description: Homo sapiens chromosome 3 open reading frame 33 (C3orf33), transcript variant 2, mRNA. (from RefSeq NM_173657)
Gencode Transcript: ENST00000534941.2
Gencode Gene: ENSG00000174928.16
Transcript (Including UTRs)
   Position: hg38 chr3:155,762,618-155,806,272 Size: 43,655 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg38 chr3:155,763,517-155,802,576 Size: 39,060 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:155,762,618-155,806,272)mRNA (may differ from genome)Protein (251 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
PubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CC033_HUMAN
DESCRIPTION: RecName: Full=Uncharacterized protein C3orf33;
SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential).
SEQUENCE CAUTION: Sequence=AAO06952.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.33 RPKM in Adrenal Gland
Total median expression: 136.23 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -64.80149-0.435 Picture PostScript Text
3' UTR -243.40899-0.271 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR006021 - Staphylococcal_nuclease

ModBase Predicted Comparative 3D Structure on Q6P1S2
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
GO:0070373 negative regulation of ERK1 and ERK2 cascade

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK055701 - Homo sapiens cDNA FLJ31139 fis, clone IMR322001185.
AF115515 - Homo sapiens MSTP052 (MST052) mRNA, complete cds.
BC064898 - Homo sapiens chromosome 3 open reading frame 33, mRNA (cDNA clone MGC:70365 IMAGE:6008321), complete cds.
AL832165 - Homo sapiens mRNA; cDNA DKFZp686E11158 (from clone DKFZp686E11158).
BC042198 - Homo sapiens chromosome 3 open reading frame 33, mRNA (cDNA clone IMAGE:5109794), partial cds.
JD553415 - Sequence 534439 from Patent EP1572962.
JD364062 - Sequence 345086 from Patent EP1572962.
JD345280 - Sequence 326304 from Patent EP1572962.
JD046292 - Sequence 27316 from Patent EP1572962.
JD069849 - Sequence 50873 from Patent EP1572962.
JD532441 - Sequence 513465 from Patent EP1572962.
AK289890 - Homo sapiens cDNA FLJ75973 complete cds.
JD262304 - Sequence 243328 from Patent EP1572962.
JD087200 - Sequence 68224 from Patent EP1572962.
JD513463 - Sequence 494487 from Patent EP1572962.
JD491988 - Sequence 473012 from Patent EP1572962.
JD295678 - Sequence 276702 from Patent EP1572962.
JD262345 - Sequence 243369 from Patent EP1572962.
JD154222 - Sequence 135246 from Patent EP1572962.
JD198770 - Sequence 179794 from Patent EP1572962.
JD388563 - Sequence 369587 from Patent EP1572962.
JD152958 - Sequence 133982 from Patent EP1572962.
JD198312 - Sequence 179336 from Patent EP1572962.
JD140585 - Sequence 121609 from Patent EP1572962.
JD388562 - Sequence 369586 from Patent EP1572962.
JD491986 - Sequence 473010 from Patent EP1572962.
JD523618 - Sequence 504642 from Patent EP1572962.
JD281398 - Sequence 262422 from Patent EP1572962.
JD160748 - Sequence 141772 from Patent EP1572962.
JD281397 - Sequence 262421 from Patent EP1572962.
JD152957 - Sequence 133981 from Patent EP1572962.
JD557917 - Sequence 538941 from Patent EP1572962.
JD326398 - Sequence 307422 from Patent EP1572962.
JD480449 - Sequence 461473 from Patent EP1572962.
JD108077 - Sequence 89101 from Patent EP1572962.
JD108078 - Sequence 89102 from Patent EP1572962.
JD413749 - Sequence 394773 from Patent EP1572962.
JD213084 - Sequence 194108 from Patent EP1572962.
JD542922 - Sequence 523946 from Patent EP1572962.
JD165234 - Sequence 146258 from Patent EP1572962.
JD262081 - Sequence 243105 from Patent EP1572962.
JD087078 - Sequence 68102 from Patent EP1572962.
JD448871 - Sequence 429895 from Patent EP1572962.
JD440612 - Sequence 421636 from Patent EP1572962.
JD558173 - Sequence 539197 from Patent EP1572962.
JD236269 - Sequence 217293 from Patent EP1572962.
KJ905070 - Synthetic construct Homo sapiens clone ccsbBroadEn_14464 C3orf33 gene, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K1H5, CC033_HUMAN, ENST00000534941.1, MSTP052, NM_173657, Q6P1S2, Q86YE6, Q8IXA7, uc062pfq.1
UCSC ID: ENST00000534941.2
RefSeq Accession: NM_001308229
Protein: Q6P1S2 (aka CC033_HUMAN)
CCDS: CCDS54659.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.