Human Gene SPOCK3 (ENST00000504953.5) from GENCODE V44
Description: May participate in diverse steps of neurogenesis. Inhibits the processing of pro-matrix metalloproteinase 2 (MMP-2) by MT1-MMP and MT3-MMP. May interfere with tumor invasion. (from UniProt Q9BQ16) RefSeq Summary (NM_001040159): This gene encodes a member of a novel family of calcium-binding proteoglycan proteins that contain thyroglobulin type-1 and Kazal-like domains. The encoded protein and may play a role in adult T-cell leukemia by inhibiting the activity of membrane-type matrix metalloproteinases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]. Gencode Transcript: ENST00000504953.5 Gencode Gene: ENSG00000196104.11 Transcript (Including UTRs) Position: hg38 chr4:166,733,387-167,234,757 Size: 501,371 Total Exon Count: 11 Strand: - Coding Region Position: hg38 chr4:166,734,921-167,234,173 Size: 499,253 Coding Exon Count: 10
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF07648 - Kazal-type serine protease inhibitor domain PF10591 - Secreted protein acidic and rich in cysteine Ca binding region PF00086 - Thyroglobulin type-1 repeat
ModBase Predicted Comparative 3D Structure on Q9BQ16
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
