Human Gene UIMC1 (ENST00000511320.6) from GENCODE V44
Description: Homo sapiens ubiquitin interaction motif containing 1 (UIMC1), transcript variant 6, non-coding RNA. (from RefSeq NR_146150) RefSeq Summary (NM_001199298): This gene encodes a nuclear protein that interacts with Brca1 (breast cancer 1) in a complex to recognize and repair DNA lesions. This protein binds ubiquitinated lysine 63 of histone H2A and H2AX. This protein may also function as a repressor of transcription. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]. Gencode Transcript: ENST00000511320.6 Gencode Gene: ENSG00000087206.17 Transcript (Including UTRs) Position: hg38 chr5:176,905,006-177,006,779 Size: 101,774 Total Exon Count: 15 Strand: - Coding Region Position: hg38 chr5:176,905,282-176,982,615 Size: 77,334 Coding Exon Count: 14
ID:UIMC1_HUMAN DESCRIPTION: RecName: Full=BRCA1-A complex subunit RAP80; AltName: Full=Receptor-associated protein 80; AltName: Full=Retinoid X receptor-interacting protein 110; AltName: Full=Ubiquitin interaction motif-containing protein 1; FUNCTION: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. SUBUNIT: Interacts with TSP57 (By similarity). Component of the BRCA1-A complex, at least composed of the BRCA1, BARD1, UIMC1/RAP80, FAM175A/Abraxas, BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1. In the BRCA1-A complex, interacts directly with FAM175A/Abraxas. Interacts with ESR1, NR6A1 and UBE2I. INTERACTION: P38398:BRCA1; NbExp=9; IntAct=EBI-725300, EBI-349905; Q6UWZ7:FAM175A; NbExp=9; IntAct=EBI-725300, EBI-1263451; SUBCELLULAR LOCATION: Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs). TISSUE SPECIFICITY: Expressed in testis, ovary, thymus and heart. Expressed in germ cells of the testis. DOMAIN: The UIM-linker region between the 2 UIM repeats determines the selectivity for 'Lys-63'-linked ubiquitin. The length of the linker is important. The linker reduces the flexibility between the UIM repeats and promotes high-affinity and linkage-selective interactions. DOMAIN: The Abraxas-interacting region (AIR) mediates the interaction with FAM175A/Abraxas. PTM: Sumoylated. PTM: Phosphorylated upon DNA damage by ATM or ATR. SIMILARITY: Belongs to the RAP80 family. SIMILARITY: Contains 2 UIM (ubiquitin-interacting motif) repeats. SEQUENCE CAUTION: Sequence=AAH06078.1; Type=Erroneous termination; Positions=386; Note=Translated as Glu;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96RL1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006281 DNA repair GO:0006302 double-strand break repair GO:0006303 double-strand break repair via nonhomologous end joining GO:0006325 chromatin organization GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006974 cellular response to DNA damage stimulus GO:0010212 response to ionizing radiation GO:0016579 protein deubiquitination GO:0045739 positive regulation of DNA repair GO:0045892 negative regulation of transcription, DNA-templated GO:0070537 histone H2A K63-linked deubiquitination GO:0072425 signal transduction involved in G2 DNA damage checkpoint
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