Human Gene ITPR3 (ENST00000374316.9) from GENCODE V44
Description: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. (from UniProt Q14573) RefSeq Summary (NM_002224): This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. [provided by RefSeq, Aug 2010]. Gencode Transcript: ENST00000374316.9 Gencode Gene: ENSG00000096433.11 Transcript (Including UTRs) Position: hg38 chr6:33,620,365-33,696,574 Size: 76,210 Total Exon Count: 59 Strand: + Coding Region Position: hg38 chr6:33,621,603-33,695,780 Size: 74,178 Coding Exon Count: 58
ID:ITPR3_HUMAN DESCRIPTION: RecName: Full=Inositol 1,4,5-trisphosphate receptor type 3; AltName: Full=IP3 receptor isoform 3; Short=IP3R 3; Short=InsP3R3; AltName: Full=Type 3 inositol 1,4,5-trisphosphate receptor; Short=Type 3 InsP3 receptor; FUNCTION: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. SUBUNIT: Homotetramer. Interacts with SIGMAR1, PML, AKT1, TRPC1, TRPC3 and TRPC4 (By similarity). Interacts with CABP1. Interacts with TMBIM4/LFG4. INTERACTION: Q13507:TRPC3; NbExp=5; IntAct=EBI-351055, EBI-520807; SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in intestinal crypt and villus epithelial cells. DOMAIN: The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand- binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. PTM: Phosphorylated on tyrosine residues. Phosphorylated by AKT1 on serine and/or threonine residues (By similarity). SIMILARITY: Belongs to the InsP3 receptor family. SIMILARITY: Contains 5 MIR domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF08709 - Inositol 1,4,5-trisphosphate/ryanodine receptor PF00520 - Ion transport protein PF02815 - MIR domain PF08454 - RyR and IP3R Homology associated PF01365 - RIH domain
ModBase Predicted Comparative 3D Structure on Q14573
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006811 ion transport GO:0006816 calcium ion transport GO:0007186 G-protein coupled receptor signaling pathway GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0007613 memory GO:0030168 platelet activation GO:0048016 inositol phosphate-mediated signaling GO:0050796 regulation of insulin secretion GO:0050913 sensory perception of bitter taste GO:0050916 sensory perception of sweet taste GO:0050917 sensory perception of umami taste GO:0051209 release of sequestered calcium ion into cytosol GO:0051260 protein homooligomerization GO:0051291 protein heterooligomerization GO:0051592 response to calcium ion GO:0055085 transmembrane transport GO:0060291 long-term synaptic potentiation GO:0060402 calcium ion transport into cytosol GO:0070588 calcium ion transmembrane transport GO:1903779 regulation of cardiac conduction
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