Human Gene CCNE2 (ENST00000520509.5) from GENCODE V44
Description: Essential for the control of the cell cycle at the late G1 and early S phase. (from UniProt O96020) RefSeq Summary (NM_057749): The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000520509.5 Gencode Gene: ENSG00000175305.18 Transcript (Including UTRs) Position: hg38 chr8:94,879,770-94,896,678 Size: 16,909 Total Exon Count: 12 Strand: - Coding Region Position: hg38 chr8:94,881,632-94,894,221 Size: 12,590 Coding Exon Count: 11
ID:CCNE2_HUMAN DESCRIPTION: RecName: Full=G1/S-specific cyclin-E2; FUNCTION: Essential for the control of the cell cycle at the late G1 and early S phase. SUBUNIT: Interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. INTERACTION: P24941:CDK2; NbExp=5; IntAct=EBI-375033, EBI-375096; P38936:CDKN1A; NbExp=2; IntAct=EBI-375033, EBI-375077; P46527:CDKN1B; NbExp=2; IntAct=EBI-375033, EBI-519280; SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: According to PubMed:9858585, highest levels of expression in adult testis, thymus and brain. Lower levels in placenta, spleen and colon. Consistently elevated levels in tumor- derived cells compared to non-transformed proliferating cells. According to PubMed:9840927: low levels in thymus, prostate, brain, skeletal muscle, and kidney. Elevated levels in lung. According to PubMed:9840943 highly expressed in testis, placenta, thymus and brain. In a lesser extent in small intestine and colon. INDUCTION: Activated by papilloma viral oncoproteins E6 and E7 which bind to and inactivate p53 and Rb, respectively. PTM: Phosphorylation by CDK2 triggers its release from CDK2 and degradation via the ubiquitin proteasome pathway (By similarity). SIMILARITY: Belongs to the cyclin family. Cyclin E subfamily. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/ccne2/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O96020
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04110 - Cell cycle hsa04114 - Oocyte meiosis hsa04115 - p53 signaling pathway hsa05200 - Pathways in cancer hsa05215 - Prostate cancer hsa05222 - Small cell lung cancer
Reactome (by CSHL, EBI, and GO)
Protein O96020 (Reactome details) participates in the following event(s):
R-HSA-69191 Formation of Cyclin E:Cdk2 complexes R-HSA-69199 Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A R-HSA-69195 Phosphorylation of Cyclin E:Cdk2 complexes by Wee-1 R-HSA-188386 Association of Rb with Cyclin E:Cdk2 complexes R-HSA-188350 CAK-mediated phosphorylation of Cyclin E:Cdk2 R-HSA-69562 Inactivation of Cyclin E:Cdk2 complexes by p27/p21 R-HSA-157906 Translocation of Cyclin E:Cdk2 complex to the nucleus R-HSA-390470 Association of CCT/TriC with other substrates during biosynthesis (unknown chaperone) R-HSA-188390 Cyclin E:Cdk2-mediated phosphorylation of Rb R-HSA-1363303 p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 R-HSA-1363306 p130 (RBL2) binds Cyclin E/A:CDK2 R-HSA-1363311 p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 R-HSA-1363314 p107 (RBL1) binds CyclinE/A:CDK2 R-HSA-187520 Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21 R-HSA-187552 Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex R-HSA-69005 Cdc6 protein is phosphorylated by CDK R-HSA-187575 Ubiquitination of phospho-p27/p21 R-HSA-69202 Cyclin E associated events during G1/S transition R-HSA-69563 p53-Dependent G1 DNA Damage Response R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence R-HSA-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-69206 G1/S Transition R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis R-HSA-69200 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint R-HSA-2559583 Cellular Senescence R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes R-HSA-1538133 G0 and Early G1 R-HSA-453279 Mitotic G1-G1/S phases R-HSA-390466 Chaperonin-mediated protein folding R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69615 G1/S DNA Damage Checkpoints R-HSA-2262752 Cellular responses to stress R-HSA-3700989 Transcriptional Regulation by TP53 R-HSA-69278 Cell Cycle (Mitotic) R-HSA-391251 Protein folding R-HSA-69242 S Phase R-HSA-69052 Switching of origins to a post-replicative state R-HSA-69620 Cell Cycle Checkpoints R-HSA-8953897 Cellular responses to external stimuli R-HSA-212436 Generic Transcription Pathway R-HSA-1640170 Cell Cycle R-HSA-392499 Metabolism of proteins R-HSA-69239 Synthesis of DNA R-HSA-73857 RNA Polymerase II Transcription R-HSA-69306 DNA Replication R-HSA-74160 Gene expression (Transcription)
US Server
