Mouse Gene Clic6 (ENSMUST00000023670.3) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus chloride intracellular channel 6 (Clic6), mRNA. (from RefSeq NM_172469)
Gencode Transcript: ENSMUST00000023670.3
Gencode Gene: ENSMUSG00000022949.9
Transcript (Including UTRs)
   Position: mm10 chr16:92,498,134-92,541,243 Size: 43,110 Total Exon Count: 6 Strand: +
Coding Region
   Position: mm10 chr16:92,498,454-92,539,596 Size: 41,143 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:92,498,134-92,541,243)mRNA (may differ from genome)Protein (596 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSCGAP
EnsemblEntrez GeneExonPrimerGeneCardsMGIPubMed
Stanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: CLIC6_MOUSE
DESCRIPTION: RecName: Full=Chloride intracellular channel protein 6;
FUNCTION: May insert into membranes and form chloride ion channels. May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport (By similarity).
SUBUNIT: Interacts with dopamine receptors DRD2, DRD3 and DRD4 (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell membrane; Single-pass membrane protein (By similarity). Note=Predominantly cytoplasmic. Upon chloride ion efflux from the cell, it is translocated to the plasma membrane (By similarity).
DOMAIN: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion (By similarity).
PTM: Phosphorylated (By similarity).
SIMILARITY: Belongs to the chloride channel CLIC family.
SIMILARITY: Contains 1 GST C-terminal domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -114.70320-0.358 Picture PostScript Text
3' UTR -492.401647-0.299 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR010987 - Glutathione-S-Trfase_C-like
IPR017933 - Glutathione_S_Trfase/Cl_chnl_C
IPR002946 - Int_Cl_channel
IPR012336 - Thioredoxin-like_fold

Pfam Domains:
PF13410 - Glutathione S-transferase, C-terminal domain

SCOP Domains:
47616 - GST C-terminal domain-like
52833 - Thioredoxin-like

ModBase Predicted Comparative 3D Structure on Q8BHB9
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005244 voltage-gated ion channel activity
GO:0005254 chloride channel activity
GO:0008022 protein C-terminus binding
GO:0031749 D2 dopamine receptor binding
GO:0031750 D3 dopamine receptor binding
GO:0031751 D4 dopamine receptor binding
GO:0042803 protein homodimerization activity
GO:0004364 glutathione transferase activity

Biological Process:
GO:0006811 ion transport
GO:0006821 chloride transport
GO:0034765 regulation of ion transmembrane transport
GO:1902476 chloride transmembrane transport
GO:0006749 glutathione metabolic process

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0034707 chloride channel complex


-  Descriptions from all associated GenBank mRNAs
  BC075706 - Mus musculus chloride intracellular channel 6, mRNA (cDNA clone MGC:78011 IMAGE:2648653), complete cds.
AK077599 - Mus musculus 8 days embryo whole body cDNA, RIKEN full-length enriched library, clone:5730466J16 product:CHLORIDE INTRACELLULAR CHANNEL 6 (FRAGMENT) homolog [Homo sapiens], full insert sequence.
AF448440 - Mus musculus chloride channel (Clic6) mRNA, complete cds.

-  Other Names for This Gene
  Alternate Gene Symbols: CLIC6_MOUSE, NM_172469, Q8BHB9, uc007zzg.1, uc007zzg.2
UCSC ID: uc007zzg.2
RefSeq Accession: NM_172469
Protein: Q8BHB9 (aka CLIC6_MOUSE or CLI6_MOUSE)
CCDS: CCDS28338.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.