ID:OPSD_MOUSE DESCRIPTION: RecName: Full=Rhodopsin; FUNCTION: Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal. BIOPHYSICOCHEMICAL PROPERTIES: Absorption: Abs(max)=495 nm; SUBUNIT: Homodimer (By similarity). SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Note=Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to the rod outer segment (OS) photosensory cilia (By similarity). TISSUE SPECIFICITY: Rod-shaped photoreceptor cells which mediate vision in dim light. PTM: Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region. PTM: Contains one covalently linked retinal chromophore (By similarity). DISRUPTION PHENOTYPE: Mice show no response in electroretinograms at low light intensity. They fail to form rod outer segments leading to degeneration of photoreceptor cells within 3 months of birth. SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00001 - 7 transmembrane receptor (rhodopsin family) PF10320 - Serpentine type 7TM GPCR chemoreceptor Srsx PF10323 - Serpentine type 7TM GPCR chemoreceptor Srv PF10324 - Serpentine type 7TM GPCR chemoreceptor Srw PF10413 - Amino terminal of the G-protein receptor rhodopsin
SCOP Domains: 81321 - Family A G protein-coupled receptor-like
ModBase Predicted Comparative 3D Structure on P15409
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.