Mouse Gene Rho (ENSMUST00000032471.8) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus rhodopsin (Rho), mRNA. (from RefSeq NM_145383)
Gencode Transcript: ENSMUST00000032471.8
Gencode Gene: ENSMUSG00000030324.8
Transcript (Including UTRs)
   Position: mm10 chr6:115,931,748-115,940,036 Size: 8,289 Total Exon Count: 5 Strand: +
Coding Region
   Position: mm10 chr6:115,932,005-115,936,719 Size: 4,715 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:115,931,748-115,940,036)mRNA (may differ from genome)Protein (348 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
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PubMedReactomeStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: OPSD_MOUSE
DESCRIPTION: RecName: Full=Rhodopsin;
FUNCTION: Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal.
BIOPHYSICOCHEMICAL PROPERTIES: Absorption: Abs(max)=495 nm;
SUBUNIT: Homodimer (By similarity).
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Note=Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to the rod outer segment (OS) photosensory cilia (By similarity).
TISSUE SPECIFICITY: Rod-shaped photoreceptor cells which mediate vision in dim light.
PTM: Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.
PTM: Contains one covalently linked retinal chromophore (By similarity).
DISRUPTION PHENOTYPE: Mice show no response in electroretinograms at low light intensity. They fail to form rod outer segments leading to degeneration of photoreceptor cells within 3 months of birth.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -98.90257-0.385 Picture PostScript Text
3' UTR -1143.503317-0.345 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR001760 - Opsin
IPR000732 - Rhodopsin
IPR019477 - Rhodopsin_N

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)
PF10320 - Serpentine type 7TM GPCR chemoreceptor Srsx
PF10323 - Serpentine type 7TM GPCR chemoreceptor Srv
PF10324 - Serpentine type 7TM GPCR chemoreceptor Srw
PF10413 - Amino terminal of the G-protein receptor rhodopsin

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on P15409
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
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Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0005502 11-cis retinal binding
GO:0005515 protein binding
GO:0008020 G-protein coupled photoreceptor activity
GO:0009881 photoreceptor activity
GO:0016918 retinal binding
GO:0030507 spectrin binding
GO:0046872 metal ion binding

Biological Process:
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007601 visual perception
GO:0007602 phototransduction
GO:0009416 response to light stimulus
GO:0009583 detection of light stimulus
GO:0009585 red, far-red light phototransduction
GO:0016038 absorption of visible light
GO:0016056 rhodopsin mediated signaling pathway
GO:0018298 protein-chromophore linkage
GO:0045494 photoreceptor cell maintenance
GO:0050896 response to stimulus
GO:0050953 sensory perception of light stimulus
GO:0060041 retina development in camera-type eye
GO:0071482 cellular response to light stimulus

Cellular Component:
GO:0001750 photoreceptor outer segment
GO:0001917 photoreceptor inner segment
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030867 rough endoplasmic reticulum membrane
GO:0042622 photoreceptor outer segment membrane
GO:0042995 cell projection
GO:0060342 photoreceptor inner segment membrane
GO:0097381 photoreceptor disc membrane


-  Descriptions from all associated GenBank mRNAs
  AK044333 - Mus musculus adult retina cDNA, RIKEN full-length enriched library, clone:A930007N17 product:RHODOPSIN, full insert sequence.
AK044412 - Mus musculus adult retina cDNA, RIKEN full-length enriched library, clone:A930011G12 product:RHODOPSIN, full insert sequence.
BC094460 - Mus musculus rhodopsin, mRNA (cDNA clone IMAGE:4482012).
BC031766 - Mus musculus rhodopsin, mRNA (cDNA clone MGC:25387 IMAGE:4527040), complete cds.
BC013125 - Mus musculus rhodopsin, mRNA (cDNA clone MGC:21585 IMAGE:4500760), complete cds.
AK164314 - Mus musculus 12 days embryo spinal ganglion cDNA, RIKEN full-length enriched library, clone:D130033I21 product:hypothetical protein, full insert sequence.
BC029973 - Mus musculus, clone IMAGE:5367880, mRNA.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu04744 - Phototransduction

Reactome (by CSHL, EBI, and GO)

Protein P15409 (Reactome details) participates in the following event(s):

R-MMU-74101 Photons induce isomerization of 11c-retinyl to at-retinyl
R-MMU-2454118 11cRAL binds to opsin to form 11c-retinyl:RHO
R-MMU-2581474 GRK1,4,7 phosphorylate MII to p-MII
R-MMU-74948 PP2A dephosphorylates p-RHO to RHO
R-MMU-2632521 at-retinyl is hydrolysed from p-MII:SAG to release atRAL
R-MMU-419841 Light stimulates opsin receptors
R-MMU-5620914 ARF4:GTP binds VxPx-motifs of membrane proteins
R-MMU-8982637 Opsins binds G alpha-t
R-MMU-8982640 G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t)
R-MMU-5623519 RAB3IP and RAB8A bind to the ciliary targeting complex
R-MMU-5623513 ASAP1 stimulates GTPase activity of ARF4
R-MMU-420883 Opsins act as GEFs for G alpha-t
R-MMU-5620921 ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex
R-MMU-5623521 RAB3IP stimulates nucleotide exchange on RAB8A
R-MMU-5623524 The exocyst complex binds to RAB3IP in the ciliary targeting complex
R-MMU-2485179 Activation of the phototransduction cascade
R-MMU-2453902 The canonical retinoid cycle in rods (twilight vision)
R-MMU-2514859 Inactivation, recovery and regulation of the phototransduction cascade
R-MMU-2514856 The phototransduction cascade
R-MMU-2187338 Visual phototransduction
R-MMU-419771 Opsins
R-MMU-5620916 VxPx cargo-targeting to cilium
R-MMU-418594 G alpha (i) signalling events
R-MMU-373076 Class A/1 (Rhodopsin-like receptors)
R-MMU-5620920 Cargo trafficking to the periciliary membrane
R-MMU-388396 GPCR downstream signalling
R-MMU-500792 GPCR ligand binding
R-MMU-5617833 Cilium Assembly
R-MMU-372790 Signaling by GPCR
R-MMU-1852241 Organelle biogenesis and maintenance
R-MMU-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: NM_145383, OPSD_MOUSE, P15409, Q8K0D8, Q96DZ2, uc009djk.1, uc009djk.2
UCSC ID: uc009djk.2
RefSeq Accession: NM_145383
Protein: P15409 (aka OPSD_MOUSE)
CCDS: CCDS20446.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.