Mouse Gene Npm2 (ENSMUST00000062629.4) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus nucleophosmin/nucleoplasmin 2 (Npm2), mRNA. (from RefSeq NM_181345)
Gencode Transcript: ENSMUST00000062629.4
Gencode Gene: ENSMUSG00000047911.6
Transcript (Including UTRs)
   Position: mm10 chr14:70,647,302-70,653,084 Size: 5,783 Total Exon Count: 9 Strand: -
Coding Region
   Position: mm10 chr14:70,647,505-70,652,589 Size: 5,085 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr14:70,647,302-70,653,084)mRNA (may differ from genome)Protein (207 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Nucleoplasmin-2;
FUNCTION: Core histones chaperone involved in chromatin reprogramming, specially during fertilization and early embryonic development. Probably involved in sperm DNA decondensation during fertilization.
SUBUNIT: Homopentamer, when bound to H2A-H2B dimers only. Homodecamer of two stacked pentamers, when bound to H2A-H2B dimers and H3-H4 tetramers simultaneously (By similarity).
SUBCELLULAR LOCATION: Nucleus. Note=Found in the oocyte nucleus before nuclear membrane breakdown, after which it is redistributed to the cytoplasm.
DOMAIN: The acidic tract A2 mediates histone binding (By similarity).
SIMILARITY: Belongs to the nucleoplasmin family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -33.48170-0.197 Picture PostScript Text
3' UTR -74.20203-0.366 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004301 - Nucleoplasmin
IPR024057 - Nucleoplasmin_core

Pfam Domains:
PF03066 - Nucleoplasmin

SCOP Domains:
48371 - ARM repeat
69203 - Nucleoplasmin-like core domain

ModBase Predicted Comparative 3D Structure on Q80W85
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003682 chromatin binding
GO:0019899 enzyme binding

Biological Process:
GO:0001824 blastocyst development
GO:0006325 chromatin organization
GO:0006338 chromatin remodeling
GO:0007096 regulation of exit from mitosis
GO:0007275 multicellular organism development
GO:0007338 single fertilization
GO:0009994 oocyte differentiation
GO:0043085 positive regulation of catalytic activity
GO:0045740 positive regulation of DNA replication
GO:0045836 positive regulation of meiotic nuclear division
GO:0051054 positive regulation of DNA metabolic process
GO:0051260 protein homooligomerization

Cellular Component:
GO:0000789 cytoplasmic chromatin
GO:0000790 nuclear chromatin
GO:0005634 nucleus

-  Descriptions from all associated GenBank mRNAs
  AY262112 - Mus musculus nucleoplasmin 2 (Npm2) mRNA, complete cds.
AK054533 - Mus musculus 2 days pregnant adult female ovary cDNA, RIKEN full-length enriched library, clone:E330038E07 product:hypothetical Nucleoplasmin/Glutamic acid-rich region containing protein, full insert sequence.
BC104058 - Mus musculus nucleophosmin/nucleoplasmin 2, mRNA (cDNA clone MGC:123506 IMAGE:40040361), complete cds.
BC104059 - Mus musculus nucleophosmin/nucleoplasmin 2, mRNA (cDNA clone MGC:123507 IMAGE:40040362), complete cds.
BC048751 - Mus musculus nucleophosmin/nucleoplasmin 2, mRNA (cDNA clone IMAGE:6533891).
AK139497 - Mus musculus 2 cells egg cDNA, RIKEN full-length enriched library, clone:B020001E21 product:nucleophosmin/nucleoplasmin 2, full insert sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_181345, NPM2_MOUSE, Q80W85, Q8BW23, uc007uot.1, uc007uot.2
UCSC ID: uc007uot.2
RefSeq Accession: NM_181345
Protein: Q80W85 (aka NPM2_MOUSE)
CCDS: CCDS27261.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.