Mouse Gene Npm2 (ENSMUST00000062629.4) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus nucleophosmin/nucleoplasmin 2 (Npm2), mRNA. (from RefSeq NM_181345)
Gencode Transcript: ENSMUST00000062629.4
Gencode Gene: ENSMUSG00000047911.6
Transcript (Including UTRs)
   Position: mm10 chr14:70,647,302-70,653,084 Size: 5,783 Total Exon Count: 9 Strand: -
Coding Region
   Position: mm10 chr14:70,647,505-70,652,589 Size: 5,085 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:70,647,302-70,653,084)mRNA (may differ from genome)Protein (207 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: NPM2_MOUSE
DESCRIPTION: RecName: Full=Nucleoplasmin-2;
FUNCTION: Core histones chaperone involved in chromatin reprogramming, specially during fertilization and early embryonic development. Probably involved in sperm DNA decondensation during fertilization.
SUBUNIT: Homopentamer, when bound to H2A-H2B dimers only. Homodecamer of two stacked pentamers, when bound to H2A-H2B dimers and H3-H4 tetramers simultaneously (By similarity).
SUBCELLULAR LOCATION: Nucleus. Note=Found in the oocyte nucleus before nuclear membrane breakdown, after which it is redistributed to the cytoplasm.
TISSUE SPECIFICITY: Ovary specific.
DOMAIN: The acidic tract A2 mediates histone binding (By similarity).
SIMILARITY: Belongs to the nucleoplasmin family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -33.48170-0.197 Picture PostScript Text
3' UTR -74.20203-0.366 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004301 - Nucleoplasmin
IPR024057 - Nucleoplasmin_core

Pfam Domains:
PF03066 - Nucleoplasmin

SCOP Domains:
48371 - ARM repeat
69203 - Nucleoplasmin-like core domain

ModBase Predicted Comparative 3D Structure on Q80W85
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
 RGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003682 chromatin binding
GO:0019899 enzyme binding

Biological Process:
GO:0001824 blastocyst development
GO:0006325 chromatin organization
GO:0006338 chromatin remodeling
GO:0007096 regulation of exit from mitosis
GO:0007275 multicellular organism development
GO:0007338 single fertilization
GO:0009994 oocyte differentiation
GO:0043085 positive regulation of catalytic activity
GO:0045740 positive regulation of DNA replication
GO:0045836 positive regulation of meiotic nuclear division
GO:0051054 positive regulation of DNA metabolic process
GO:0051260 protein homooligomerization

Cellular Component:
GO:0000789 cytoplasmic chromatin
GO:0000790 nuclear chromatin
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AY262112 - Mus musculus nucleoplasmin 2 (Npm2) mRNA, complete cds.
AK054533 - Mus musculus 2 days pregnant adult female ovary cDNA, RIKEN full-length enriched library, clone:E330038E07 product:hypothetical Nucleoplasmin/Glutamic acid-rich region containing protein, full insert sequence.
BC104058 - Mus musculus nucleophosmin/nucleoplasmin 2, mRNA (cDNA clone MGC:123506 IMAGE:40040361), complete cds.
BC104059 - Mus musculus nucleophosmin/nucleoplasmin 2, mRNA (cDNA clone MGC:123507 IMAGE:40040362), complete cds.
BC048751 - Mus musculus nucleophosmin/nucleoplasmin 2, mRNA (cDNA clone IMAGE:6533891).
AK139497 - Mus musculus 2 cells egg cDNA, RIKEN full-length enriched library, clone:B020001E21 product:nucleophosmin/nucleoplasmin 2, full insert sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_181345, NPM2_MOUSE, Q80W85, Q8BW23, uc007uot.1, uc007uot.2
UCSC ID: uc007uot.2
RefSeq Accession: NM_181345
Protein: Q80W85 (aka NPM2_MOUSE)
CCDS: CCDS27261.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.