Mouse Gene Runx1 (ENSMUST00000113956.9) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus runt related transcription factor 1 (Runx1), transcript variant 4, mRNA. (from RefSeq NM_009821)
Gencode Transcript: ENSMUST00000113956.9
Gencode Gene: ENSMUSG00000022952.17
Transcript (Including UTRs)
   Position: mm10 chr16:92,603,656-92,697,328 Size: 93,673 Total Exon Count: 5 Strand: -
Coding Region
   Position: mm10 chr16:92,605,655-92,695,753 Size: 90,099 Coding Exon Count: 5 

Page IndexSequence and LinksCTDRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:92,603,656-92,697,328)mRNA (may differ from genome)Protein (387 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedReactomeStanford SOURCEUniProtKBWikipedia

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -485.301575-0.308 Picture PostScript Text
3' UTR -531.801999-0.266 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR013524 - AML1/Runt_N
IPR000040 - AML1_Runt
IPR008967 - p53-like_TF_DNA-bd
IPR012346 - p53/RUNT-type_TF_DNA-bd
IPR013711 - RunxI
IPR016554 - TF_Runt-rel_RUNX

Pfam Domains:
PF00853 - Runt domain
PF08504 - Runx inhibition domain

SCOP Domains:
49417 - p53-like transcription factors

ModBase Predicted Comparative 3D Structure on G3X9W7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserNo orthologNo orthologGenome BrowserNo orthologNo ortholog
Gene Details     
Gene Sorter     
   Ensembl  
Protein Sequence  Protein Sequence  
Alignment  Alignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0005524 ATP binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AK145098 - Mus musculus mammary gland RCB-0526 Jyg-MC(A) cDNA, RIKEN full-length enriched library, clone:G830041K20 product:runt related transcription factor 1, full insert sequence.
AK137493 - Mus musculus adult male bone cDNA, RIKEN full-length enriched library, clone:9830114D24 product:runt related transcription factor 1, full insert sequence.
AK165307 - Mus musculus 6 days neonate spleen cDNA, RIKEN full-length enriched library, clone:F430011O05 product:unclassifiable, full insert sequence.
AK051758 - Mus musculus 12 days embryo spinal ganglion cDNA, RIKEN full-length enriched library, clone:D130073O22 product:runt related transcription factor 1, full insert sequence.
D26532 - Mus musculus PEBP2aB2 mRNA for transcription factor, complete cds.
BC069929 - Mus musculus runt related transcription factor 1, mRNA (cDNA clone MGC:78210 IMAGE:4008335), complete cds.
D13802 - Mus musculus mRNA for PEBP2aB protein, complete cds.
AK153274 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830130P15 product:runt related transcription factor 1, full insert sequence.
AK155262 - Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630212H16 product:runt related transcription factor 1, full insert sequence.
X97306 - M.musculus mRNA for CBFA2 protein.
AB352489 - Mus musculus non-coding RNA, oocyte_piRNA3305, complete sequence.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu05200 - Pathways in cancer
mmu05220 - Chronic myeloid leukemia
mmu05221 - Acute myeloid leukemia

Reactome (by CSHL, EBI, and GO)

Protein G3X9W7 (Reactome details) participates in the following event(s):

R-MMU-8865320 CBFB binds RUNX1
R-MMU-8938867 CCND3,(CCND1,CCND2) binds RUNX1
R-MMU-8938887 PML binds RUNX1
R-MMU-8937767 PTPN11 dephosphorylates RUNX1
R-MMU-8937744 PTPN11 binds p-7Y-RUNX1
R-MMU-8865482 KMT2A (MLL) binds RUNX1
R-MMU-8877192 RUNX1 binds FOXP3
R-MMU-8878054 HIPK2 phosphorylates RUNX1
R-MMU-8878056 RUNX1:CBFB binds EP300
R-MMU-8931981 RUNX1 binds ESR1
R-MMU-8934742 RUNX1 binds PRMT1
R-MMU-8935732 RUNX1 binds SIN3A,(SIN3B) co-repressor
R-MMU-8937989 RUNX1 binds PRC1 complexes
R-MMU-8938217 RUNX1 binds the SWI/SNF complex
R-MMU-8938231 RUNX1:CBFB binds CREBBP
R-MMU-8938913 RUNX1 binds ELF1
R-MMU-8938930 RUNX1 binds ELF2
R-MMU-8938951 RUNX1 binds PAX5 (BSAP)
R-MMU-8956568 RUNX1 binds the core TAL1 complex
R-MMU-8956639 RUNX1 binds YAP1
R-MMU-8938853 CDK6 binds RUNX1
R-MMU-8934735 PRMT1 arginine-methylates RUNX1
R-MMU-8878050 HIPK2 phosphorylates RUNX1 and EP300
R-MMU-8936584 PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter
R-MMU-8936608 PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter
R-MMU-8937022 PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter
R-MMU-8937113 PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter
R-MMU-8936481 Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter
R-MMU-8936621 Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter
R-MMU-8937016 Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter
R-MMU-8937050 Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter
R-MMU-8934593 Regulation of RUNX1 Expression and Activity
R-MMU-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-MMU-8877330 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
R-MMU-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-MMU-9018519 Estrogen-dependent gene expression
R-MMU-8931987 RUNX1 regulates estrogen receptor mediated transcription
R-MMU-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-MMU-8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
R-MMU-8939247 RUNX1 regulates transcription of genes involved in interleukin signaling
R-MMU-8939245 RUNX1 regulates transcription of genes involved in BCR signaling
R-MMU-8878171 Transcriptional regulation by RUNX1
R-MMU-8939211 ESR-mediated signaling
R-MMU-212436 Generic Transcription Pathway
R-MMU-9006931 Signaling by Nuclear Receptors
R-MMU-73857 RNA Polymerase II Transcription
R-MMU-162582 Signal Transduction
R-MMU-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: G3X9W7, G3X9W7_MOUSE, mCG_13559, NM_009821, uc012ain.1, uc012ain.2, uc012ain.3
UCSC ID: uc012ain.3
RefSeq Accession: NM_009821
Protein: G3X9W7 CCDS: CCDS28339.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.