ID:DEMA_MOUSE DESCRIPTION: RecName: Full=Dematin; AltName: Full=Erythrocyte membrane protein band 4.9; FUNCTION: Actin-bundling protein. May function in mitogen- activated protein kinase pathway (By similarity). SUBUNIT: Interacts with RASGRF2. SUBCELLULAR LOCATION: Cytoplasm (By similarity). DOMAIN: Contains at least two actin-binding sites, one in the headpiece domain and one in the N-terminal portion. DOMAIN: Consists of a large core fragment, the N-terminal portion, and a small headpiece, the C-terminal portion. The headpiece can bind but cannot bundle actin filaments. SIMILARITY: Belongs to the villin/gelsolin family. SIMILARITY: Contains 1 HP (headpiece) domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9WV69
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.