Mouse Gene Dmtn (ENSMUST00000228295.1) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus dematin actin binding protein (Dmtn), transcript variant 4, mRNA. (from RefSeq NM_001252664)
Gencode Transcript: ENSMUST00000228295.1
Gencode Gene: ENSMUSG00000022099.17
Transcript (Including UTRs)
   Position: mm10 chr14:70,603,623-70,635,978 Size: 32,356 Total Exon Count: 15 Strand: -
Coding Region
   Position: mm10 chr14:70,604,741-70,618,256 Size: 13,516 Coding Exon Count: 14 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr14:70,603,623-70,635,978)mRNA (may differ from genome)Protein (380 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
EnsemblEntrez GeneExonPrimerGeneCardsMGIPubMed
ReactomeStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Dematin; AltName: Full=Erythrocyte membrane protein band 4.9;
FUNCTION: Actin-bundling protein. May function in mitogen- activated protein kinase pathway (By similarity).
SUBUNIT: Interacts with RASGRF2.
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
DOMAIN: Contains at least two actin-binding sites, one in the headpiece domain and one in the N-terminal portion.
DOMAIN: Consists of a large core fragment, the N-terminal portion, and a small headpiece, the C-terminal portion. The headpiece can bind but cannot bundle actin filaments.
SIMILARITY: Belongs to the villin/gelsolin family.
SIMILARITY: Contains 1 HP (headpiece) domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -142.90311-0.459 Picture PostScript Text
3' UTR -401.601118-0.359 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003128 - Villin_headpiece

Pfam Domains:
PF02209 - Villin headpiece domain
PF16182 - Putative adherens-junction anchoring region of AbLIM

SCOP Domains:
47050 - VHP, Villin headpiece domain

ModBase Predicted Comparative 3D Structure on Q9WV69
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003779 actin binding
GO:0005102 receptor binding
GO:0030507 spectrin binding
GO:0043621 protein self-association

Biological Process:
GO:0007010 cytoskeleton organization
GO:0008360 regulation of cell shape
GO:0010591 regulation of lamellipodium assembly
GO:0010763 positive regulation of fibroblast migration
GO:0010801 negative regulation of peptidyl-threonine phosphorylation
GO:0010812 negative regulation of cell-substrate adhesion
GO:0030036 actin cytoskeleton organization
GO:0030194 positive regulation of blood coagulation
GO:0032956 regulation of actin cytoskeleton organization
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0035584 calcium-mediated signaling using intracellular calcium source
GO:0035585 calcium-mediated signaling using extracellular calcium source
GO:0048821 erythrocyte development
GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation
GO:0051017 actin filament bundle assembly
GO:0051489 regulation of filopodium assembly
GO:0051693 actin filament capping
GO:0051895 negative regulation of focal adhesion assembly
GO:0065003 macromolecular complex assembly
GO:0070560 protein secretion by platelet
GO:0071277 cellular response to calcium ion
GO:0071320 cellular response to cAMP
GO:0090303 positive regulation of wound healing
GO:0090315 negative regulation of protein targeting to membrane
GO:0090527 actin filament reorganization
GO:1900025 negative regulation of substrate adhesion-dependent cell spreading
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
GO:1901731 positive regulation of platelet aggregation
GO:2001046 positive regulation of integrin-mediated signaling pathway

Cellular Component:
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005884 actin filament
GO:0005886 plasma membrane
GO:0012505 endomembrane system
GO:0014069 postsynaptic density
GO:0014731 spectrin-associated cytoskeleton
GO:0016020 membrane
GO:0030863 cortical cytoskeleton
GO:0031095 platelet dense tubular network membrane
GO:0031253 cell projection membrane
GO:0031410 cytoplasmic vesicle
GO:0042995 cell projection
GO:0048471 perinuclear region of cytoplasm

-  Descriptions from all associated GenBank mRNAs
  LF200066 - JP 2014500723-A/7569: Polycomb-Associated Non-Coding RNAs.
AK165204 - Mus musculus 6 days neonate spleen cDNA, RIKEN full-length enriched library, clone:F420001J19 product:erythrocyte protein band 4.9, full insert sequence.
AK155927 - Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone:F830001B20 product:erythrocyte protein band 4.9, full insert sequence.
AK158744 - Mus musculus visual cortex cDNA, RIKEN full-length enriched library, clone:K230309O10 product:erythrocyte protein band 4.9, full insert sequence.
BC037021 - Mus musculus erythrocyte protein band 4.9, mRNA (cDNA clone MGC:46878 IMAGE:5366040), complete cds.
BC016897 - Mus musculus erythrocyte protein band 4.9, mRNA (cDNA clone MGC:18905 IMAGE:4240747), complete cds.
AK165709 - Mus musculus 15 days embryo brain cDNA, RIKEN full-length enriched library, clone:G630009O18 product:erythrocyte protein band 4.9, full insert sequence.
AK165294 - Mus musculus 6 days neonate spleen cDNA, RIKEN full-length enriched library, clone:F430010F06 product:erythrocyte protein band 4.9, full insert sequence.
AK162866 - Mus musculus adult male hypothalamus cDNA, RIKEN full-length enriched library, clone:A230065G03 product:erythrocyte protein band 4.9, full insert sequence.
AK143840 - Mus musculus 6 days neonate spleen cDNA, RIKEN full-length enriched library, clone:F430203M01 product:erythrocyte protein band 4.9, full insert sequence.
AF079846 - Mus musculus dematin 48 kDa subunit (Epb4.9) mRNA, complete cds.
AF155547 - Mus musculus dematin 52 kDa subunit mRNA, complete cds.
AK149301 - Mus musculus adult retina cDNA, RIKEN full-length enriched library, clone:A930016C13 product:erythrocyte protein band 4.9, full insert sequence.
LF241925 - JP 2014500723-A/49428: Polycomb-Associated Non-Coding RNAs.
LF241930 - JP 2014500723-A/49433: Polycomb-Associated Non-Coding RNAs.
LF241931 - JP 2014500723-A/49434: Polycomb-Associated Non-Coding RNAs.
AK046217 - Mus musculus adult male corpora quadrigemina cDNA, RIKEN full-length enriched library, clone:B230353N08 product:erythrocyte protein band 4.9, full insert sequence.
LF241932 - JP 2014500723-A/49435: Polycomb-Associated Non-Coding RNAs.
LF241933 - JP 2014500723-A/49436: Polycomb-Associated Non-Coding RNAs.
LF241936 - JP 2014500723-A/49439: Polycomb-Associated Non-Coding RNAs.
LF241942 - JP 2014500723-A/49445: Polycomb-Associated Non-Coding RNAs.
LF241962 - JP 2014500723-A/49465: Polycomb-Associated Non-Coding RNAs.
MA435643 - JP 2018138019-A/7569: Polycomb-Associated Non-Coding RNAs.
MA477502 - JP 2018138019-A/49428: Polycomb-Associated Non-Coding RNAs.
MA477507 - JP 2018138019-A/49433: Polycomb-Associated Non-Coding RNAs.
MA477508 - JP 2018138019-A/49434: Polycomb-Associated Non-Coding RNAs.
MA477509 - JP 2018138019-A/49435: Polycomb-Associated Non-Coding RNAs.
MA477510 - JP 2018138019-A/49436: Polycomb-Associated Non-Coding RNAs.
MA477513 - JP 2018138019-A/49439: Polycomb-Associated Non-Coding RNAs.
MA477519 - JP 2018138019-A/49445: Polycomb-Associated Non-Coding RNAs.
MA477539 - JP 2018138019-A/49465: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9WV69 (Reactome details) participates in the following event(s):

R-MMU-5226979 ADD1:ADD2 binds DMTN
R-MMU-5226999 ADD1:ADD3 binds DMTN
R-MMU-5223345 Miscellaneous transport and binding events
R-MMU-382551 Transport of small molecules

-  Other Names for This Gene
  Alternate Gene Symbols: DEMA_MOUSE, Epb4.9, Epb49, NM_001252664, Q9WV69, uc057ktd.1, uc057ktd.2
UCSC ID: uc057ktd.2
RefSeq Accession: NM_001252664
Protein: Q9WV69 (aka DEMA_MOUSE)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.