Human Gene ENSG00000285602 (ENST00000649243.1) from GENCODE V44
  Description: ENSG00000285602 (from geneSymbol)
RefSeq Summary (NM_021804): The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronavirus HCoV-NL63 and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2 (COVID-19 virus). [provided by RefSeq, Mar 2020].
Gencode Transcript: ENST00000649243.1
Gencode Gene: ENSG00000285602.1
Transcript (Including UTRs)
   Position: hg38 chrX:15,561,047-15,675,608 Size: 114,562 Total Exon Count: 20 Strand: -
Coding Region
   Position: hg38 chrX:15,600,990-15,659,062 Size: 58,073 Coding Exon Count: 4 

Page IndexSequence and LinksPrimersMicroarray ExpressionRNA StructureOther Species
mRNA DescriptionsPathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
Genomic Sequence (chrX:15,561,047-15,675,608)mRNA (may differ from genome)Protein (126 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS

-  Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -70.30264-0.266 Picture PostScript Text
3' UTR -843.203021-0.279 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Descriptions from all associated GenBank mRNAs
  AF291820 - Homo sapiens ACE-related carboxypeptidase ACE2 mRNA, complete cds.
BC048094 - Homo sapiens angiotensin I converting enzyme (peptidyl-dipeptidase A) 2, mRNA (cDNA clone MGC:57146 IMAGE:5297380), complete cds.
BC048144 - Homo sapiens angiotensin I converting enzyme (peptidyl-dipeptidase A) 2, mRNA (cDNA clone IMAGE:5297522).
AF241254 - Homo sapiens angiotensin converting enzyme-like protein mRNA, complete cds.
AB193260 - Homo sapiens ace2 mRNA for angiotensin-converting enzyme 2, complete cds, tissue_type: testis.
AB193259 - Homo sapiens ace2 mRNA for angiotensin-converting enzyme 2, complete cds, tissue_type: lung.
BC059378 - Homo sapiens cDNA clone IMAGE:5296531, partial cds.
BC039902 - Homo sapiens angiotensin I converting enzyme (peptidyl-dipeptidase A) 2, mRNA (cDNA clone MGC:47598 IMAGE:5243048), complete cds.
AL110224 - Homo sapiens mRNA; cDNA DKFZp434A014 (from clone DKFZp434A014); partial cds.
BC032938 - Homo sapiens cDNA clone IMAGE:4830668, containing frame-shift errors.
AY358714 - Homo sapiens clone DNA79302 ACE2 (UNQ868) mRNA, complete cds.
AB046569 - Homo sapiens ace2 mRNA, complete cds.
AY623811 - Homo sapiens angiotensin converting enzyme 2 mRNA, complete cds.
GQ262784 - Homo sapiens angiotensin I converting enzyme 2 mRNA, complete cds.
AK315144 - Homo sapiens cDNA, FLJ96113, highly similar to Homo sapiens angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 (ACE2), mRNA.
AB591025 - Synthetic construct DNA, clone: pFN21AE2097, Homo sapiens ACE2 gene for angiotensin I converting enzyme (peptidyl-dipeptidase A) 2, without stop codon, in Flexi system.
KM576721 - Homo sapiens clone TMEM27-ACE2_T4-A2middle mRNA sequence.
KM576722 - Homo sapiens clone TMEM27-ACE2_T4-A2 mRNA sequence.
KM576723 - Homo sapiens clone TMEM27-ACE2_T5-A2middle mRNA sequence.
KM576724 - Homo sapiens clone TMEM27-ACE2_T5-A2 mRNA sequence.
AK026461 - Homo sapiens cDNA: FLJ22808 fis, clone KAIA2925.
JD347792 - Sequence 328816 from Patent EP1572962.
JD048407 - Sequence 29431 from Patent EP1572962.
JD428141 - Sequence 409165 from Patent EP1572962.
JD416694 - Sequence 397718 from Patent EP1572962.
JD291971 - Sequence 272995 from Patent EP1572962.
JD257961 - Sequence 238985 from Patent EP1572962.
JD078760 - Sequence 59784 from Patent EP1572962.
JD459432 - Sequence 440456 from Patent EP1572962.
JD295277 - Sequence 276301 from Patent EP1572962.
JD305565 - Sequence 286589 from Patent EP1572962.
JD515689 - Sequence 496713 from Patent EP1572962.
MT505392 - Homo sapiens truncated angiotensin converting enzyme 2 (ACE2) mRNA, complete cds.
BC050606 - Homo sapiens transmembrane protein 27, mRNA (cDNA clone MGC:60059 IMAGE:5183554), complete cds.
AF229179 - Homo sapiens collectrin mRNA, complete cds.
BC015099 - Homo sapiens transmembrane protein 27, mRNA (cDNA clone MGC:22827 IMAGE:3829035), complete cds.
AY359060 - Homo sapiens clone DNA61873 NX-17 (UNQ678) mRNA, complete cds.
BC014317 - Homo sapiens transmembrane protein 27, mRNA (cDNA clone MGC:22707 IMAGE:4048217), complete cds.
AK313835 - Homo sapiens cDNA, FLJ94460, Homo sapiens kidney-specific membrane protein (NX17), mRNA.
KJ904836 - Synthetic construct Homo sapiens clone ccsbBroadEn_14230 TMEM27 gene, encodes complete protein.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04614 - Renin-angiotensin system

-  Other Names for This Gene
  Alternate Gene Symbols: A0A3B3IT09, AF241254, uc286crf.1
UCSC ID: ENST00000649243.1
RefSeq Accession: NM_021804

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.