Human Gene ACE2 (ENST00000678073.1)
  Description: angiotensin I converting enzyme 2 (from HGNC ACE2)
RefSeq Summary (NM_021804): The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronavirus HCoV-NL63 and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2 (COVID-19 virus). [provided by RefSeq, Mar 2020].
Gencode Transcript: ENST00000678073.1
Gencode Gene: ENSG00000130234.12
Transcript (Including UTRs)
   Position: hg38 chrX:15,557,039-15,607,236 Size: 50,198 Total Exon Count: 19 Strand: -
Coding Region
   Position: hg38 chrX:15,561,905-15,600,911 Size: 39,007 Coding Exon Count: 18 

Page IndexSequence and LinksMalaCardsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureOther SpeciesmRNA DescriptionsPathwaysOther NamesMethods
Data last updated at UCSC: 2021-01-14 15:32:12

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:15,557,039-15,607,236)mRNA (may differ from genome)Protein (805 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblExonPrimerGeneCardsHGNCLynx
MGIPubMedWikipedia

-  MalaCards Disease Associations
  MalaCards Gene Search: ACE2
Diseases sorted by gene-association score: severe acute respiratory syndrome (28), neurogenic hypertension (18), hartnup disorder (14), tetanus neonatorum (9), internal hemorrhoid (9), intracranial aneurysm (8), posterior urethral valves (6), hypertension, essential (2), myocardial infarction (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 33.78 RPKM in Small Intestine - Terminal Ileum
Total median expression: 90.25 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -46.00203-0.227 Picture PostScript Text
3' UTR -1279.174866-0.263 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Descriptions from all associated GenBank mRNAs
  AF291820 - Homo sapiens ACE-related carboxypeptidase ACE2 mRNA, complete cds.
BC048094 - Homo sapiens angiotensin I converting enzyme (peptidyl-dipeptidase A) 2, mRNA (cDNA clone MGC:57146 IMAGE:5297380), complete cds.
BC048144 - Homo sapiens angiotensin I converting enzyme (peptidyl-dipeptidase A) 2, mRNA (cDNA clone IMAGE:5297522).
AF241254 - Homo sapiens angiotensin converting enzyme-like protein mRNA, complete cds.
AB193260 - Homo sapiens ace2 mRNA for angiotensin-converting enzyme 2, complete cds, tissue_type: testis.
AB193259 - Homo sapiens ace2 mRNA for angiotensin-converting enzyme 2, complete cds, tissue_type: lung.
BC059378 - Homo sapiens cDNA clone IMAGE:5296531, partial cds.
BC039902 - Homo sapiens angiotensin I converting enzyme (peptidyl-dipeptidase A) 2, mRNA (cDNA clone MGC:47598 IMAGE:5243048), complete cds.
AL110224 - Homo sapiens mRNA; cDNA DKFZp434A014 (from clone DKFZp434A014); partial cds.
BC032938 - Homo sapiens cDNA clone IMAGE:4830668, containing frame-shift errors.
AY358714 - Homo sapiens clone DNA79302 ACE2 (UNQ868) mRNA, complete cds.
AB046569 - Homo sapiens ace2 mRNA, complete cds.
AY623811 - Homo sapiens angiotensin converting enzyme 2 mRNA, complete cds.
GQ262784 - Homo sapiens angiotensin I converting enzyme 2 mRNA, complete cds.
AK315144 - Homo sapiens cDNA, FLJ96113, highly similar to Homo sapiens angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 (ACE2), mRNA.
AB591025 - Synthetic construct DNA, clone: pFN21AE2097, Homo sapiens ACE2 gene for angiotensin I converting enzyme (peptidyl-dipeptidase A) 2, without stop codon, in Flexi system.
KM576721 - Homo sapiens clone TMEM27-ACE2_T4-A2middle mRNA sequence.
KM576722 - Homo sapiens clone TMEM27-ACE2_T4-A2 mRNA sequence.
KM576723 - Homo sapiens clone TMEM27-ACE2_T5-A2middle mRNA sequence.
KM576724 - Homo sapiens clone TMEM27-ACE2_T5-A2 mRNA sequence.
AK026461 - Homo sapiens cDNA: FLJ22808 fis, clone KAIA2925.
JD347792 - Sequence 328816 from Patent EP1572962.
JD048407 - Sequence 29431 from Patent EP1572962.
JD428141 - Sequence 409165 from Patent EP1572962.
JD416694 - Sequence 397718 from Patent EP1572962.
JD291971 - Sequence 272995 from Patent EP1572962.
JD257961 - Sequence 238985 from Patent EP1572962.
JD078760 - Sequence 59784 from Patent EP1572962.
JD459432 - Sequence 440456 from Patent EP1572962.
JD295277 - Sequence 276301 from Patent EP1572962.
JD305565 - Sequence 286589 from Patent EP1572962.
JD515689 - Sequence 496713 from Patent EP1572962.
MT505392 - Homo sapiens truncated angiotensin converting enzyme 2 (ACE2) mRNA, complete cds.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04614 - Renin-angiotensin system

BioCarta from NCI Cancer Genome Anatomy Project
h_ace2Pathway - Angiotensin-converting enzyme 2 regulates heart function

-  Other Names for This Gene
  Alternate Gene Symbols: AF241254, uc288sqw.1
UCSC ID: ENST00000678073.1
RefSeq Accession: NM_021804
CCDS: CCDS14169.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.