S. cerevisiae Gene ENT5 (YDR153C)
  Description: Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin
Transcript (Including UTRs)
   Position: sacCer3 chrIV:766,736-767,971 Size: 1,236 Total Exon Count: 1 Strand: -
Coding Region
   Position: sacCer3 chrIV:766,736-767,971 Size: 1,236 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsProtein StructureOther SpeciesGO Annotations
Other NamesMethods
Data last updated at UCSC: 2011-08-29

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrIV:766,736-767,971)mRNAProtein (411 aa)
Gene SorterGenome BrowserOther Species FASTASGDUniProtKB

-  Comments and Description Text from UniProtKB
  ID: ENT5_YEAST
DESCRIPTION: RecName: Full=Epsin-5;
FUNCTION: Involved in the recruitment of clathrin to the Golgi network and endosomes to form clathrin coated vesicles. Plays a role in the trafficking of clathrin between the Golgi network and endosomes. Binds to membranes enriched in phosphatidylinositol- 3,5-bisphosphate (PtdIns(3,5)P2) and, in association with VPS27, is involved in protein sorting at the multivesicular body (MVB).
SUBUNIT: Interacts with the clathrin adapter GGA2 and the clathrin adapter complex AP-1.
SUBCELLULAR LOCATION: Cytoplasm. Endosome membrane; Peripheral membrane protein. Note=Found predominantly on endosomal structures.
MISCELLANEOUS: Present with 8100 molecules/cell in log phase SD medium.
SIMILARITY: Contains 1 ENTH (epsin N-terminal homology) domain.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008942 - ENTH_VHS
IPR013809 - Epsin-like_N
IPR001026 - Epsin_dom_N

Pfam Domains:
PF01417 - ENTH domain

ModBase Predicted Comparative 3D Structure on Q03769
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanMouseRatZebrafishD. melanogasterC. elegans
No orthologNo orthologNo orthologNo orthologGenome BrowserGenome Browser
    Gene DetailsGene Details
    Gene SorterGene Sorter
    FlyBaseWormBase
    Protein SequenceProtein Sequence
    AlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008289 lipid binding
GO:0030276 clathrin binding
GO:0080025 phosphatidylinositol-3,5-bisphosphate binding

Biological Process:
GO:0006895 Golgi to endosome transport
GO:0015031 protein transport
GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway
GO:0034498 early endosome to Golgi transport

Cellular Component:
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005829 cytosol
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0030125 clathrin vesicle coat


-  Other Names for This Gene
  UCSC ID: YDR153C
Protein: Q03769 (aka ENT5_YEAST)

-  SGD Genes Methods, Credits, and Data Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.