S. cerevisiae Gene ENT5 (YDR153C)
  Description: Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin
Transcript (Including UTRs)
   Position: sacCer3 chrIV:766,736-767,971 Size: 1,236 Total Exon Count: 1 Strand: -
Coding Region
   Position: sacCer3 chrIV:766,736-767,971 Size: 1,236 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsProtein StructureOther SpeciesGO Annotations
Other NamesMethods
Data last updated at UCSC: 2011-08-29

-  Sequence and Links to Tools and Databases
Genomic Sequence (chrIV:766,736-767,971)mRNAProtein (411 aa)
Gene SorterGenome BrowserOther Species FASTASGDUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Epsin-5;
FUNCTION: Involved in the recruitment of clathrin to the Golgi network and endosomes to form clathrin coated vesicles. Plays a role in the trafficking of clathrin between the Golgi network and endosomes. Binds to membranes enriched in phosphatidylinositol- 3,5-bisphosphate (PtdIns(3,5)P2) and, in association with VPS27, is involved in protein sorting at the multivesicular body (MVB).
SUBUNIT: Interacts with the clathrin adapter GGA2 and the clathrin adapter complex AP-1.
SUBCELLULAR LOCATION: Cytoplasm. Endosome membrane; Peripheral membrane protein. Note=Found predominantly on endosomal structures.
MISCELLANEOUS: Present with 8100 molecules/cell in log phase SD medium.
SIMILARITY: Contains 1 ENTH (epsin N-terminal homology) domain.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008942 - ENTH_VHS
IPR013809 - Epsin-like_N
IPR001026 - Epsin_dom_N

Pfam Domains:
PF01417 - ENTH domain

ModBase Predicted Comparative 3D Structure on Q03769
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanMouseRatZebrafishD. melanogasterC. elegans
No orthologNo orthologNo orthologNo orthologGenome BrowserGenome Browser
    Gene DetailsGene Details
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    Protein SequenceProtein Sequence

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008289 lipid binding
GO:0030276 clathrin binding
GO:0080025 phosphatidylinositol-3,5-bisphosphate binding

Biological Process:
GO:0006895 Golgi to endosome transport
GO:0015031 protein transport
GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway
GO:0034498 early endosome to Golgi transport

Cellular Component:
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005829 cytosol
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0030125 clathrin vesicle coat

-  Other Names for This Gene
Protein: Q03769 (aka ENT5_YEAST)

-  SGD Genes Methods, Credits, and Data Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.