S. cerevisiae Gene CPR1 (YDR155C)
  Description: Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues binds the drug cyclosporin A
Transcript (Including UTRs)
   Position: sacCer3 chrIV:768,512-769,000 Size: 489 Total Exon Count: 1 Strand: -
Coding Region
   Position: sacCer3 chrIV:768,512-769,000 Size: 489 Coding Exon Count: 1 

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mRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2011-08-29

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrIV:768,512-769,000)mRNAProtein (162 aa)
Gene SorterGenome BrowserOther Species FASTASGDUniProtKB

-  Comments and Description Text from UniProtKB
  ID: CYPH_YEAST
DESCRIPTION: RecName: Full=Peptidyl-prolyl cis-trans isomerase; Short=PPIase; EC=5.2.1.8; AltName: Full=Cyclophilin; Short=CPH; AltName: Full=Cyclosporin A-binding protein; AltName: Full=PPI-II; AltName: Full=Rotamase;
FUNCTION: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in histone deacetylase complexes, suggesting a function in chromatin. Imports fructose-1,6- bisphosphatase (FBPase) into the intermediate vacuole import and degradation (Vid) vesicles.
CATALYTIC ACTIVITY: Peptidylproline (omega=180) = peptidylproline (omega=0).
ENZYME REGULATION: Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase.
SUBUNIT: Interacts with a complex composed of SIN3 and RPD3. Identified in the Set3C complex with HOS2, HST1, SNT1, SIF2, HOS4/YIL112W and SET3.
SUBCELLULAR LOCATION: Cytoplasm.
MISCELLANEOUS: Present with 86000 molecules/cell in log phase SD medium.
SIMILARITY: Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
SIMILARITY: Contains 1 PPIase cyclophilin-type domain.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002130 - Cyclophilin-like_PPIase_dom
IPR024936 - Cyclophilin-type_PPIase
IPR020892 - Cyclophilin-type_PPIase_CS

Pfam Domains:
PF00160 - Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD

Protein Data Bank (PDB) 3-D Structure
MuPIT help

1IST
- X-ray

1VDN
- X-ray


ModBase Predicted Comparative 3D Structure on P14832
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanMouseRatZebrafishD. melanogasterC. elegans
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