S. cerevisiae Gene HOM2 (YDR158W)
  Description: Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis expression regulated by Gcn4p and the general control of amino acid synthesis
Transcript (Including UTRs)
   Position: sacCer3 chrIV:770,357-771,454 Size: 1,098 Total Exon Count: 1 Strand: +
Coding Region
   Position: sacCer3 chrIV:770,357-771,454 Size: 1,098 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2011-08-29

-  Sequence and Links to Tools and Databases
Genomic Sequence (chrIV:770,357-771,454)mRNAProtein (365 aa)
Gene SorterGenome BrowserOther Species FASTASGDUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Aspartate-semialdehyde dehydrogenase; Short=ASA dehydrogenase; Short=ASADH; EC=; AltName: Full=Aspartate-beta-semialdehyde dehydrogenase;
FUNCTION: Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity).
CATALYTIC ACTIVITY: L-aspartate 4-semialdehyde + phosphate + NADP(+) = L-4-aspartyl phosphate + NADPH.
PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.
PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.
PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L- threonine from L-aspartate: step 2/5.
SUBUNIT: Homodimer.
INDUCTION: By high concentrations of Met (general AA biosynthesis control).
MISCELLANEOUS: Present with 18400 molecules/cell in log phase SD medium.
SIMILARITY: Belongs to the aspartate-semialdehyde dehydrogenase family.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000319 - Asp-semialdehyde_DH_CS
IPR005676 - Asp_semi-ald_DH_pep-lack
IPR012080 - Asp_semialdehyde_DH
IPR016040 - NAD(P)-bd_dom
IPR000534 - Semialdehyde_DH_NAD-bd
IPR012280 - Semialdhyde_DH_dimer_dom

Pfam Domains:
PF01118 - Semialdehyde dehydrogenase, NAD binding domain
PF02774 - Semialdehyde dehydrogenase, dimerisation domain

ModBase Predicted Comparative 3D Structure on P13663
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanMouseRatZebrafishD. melanogasterC. elegans
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004073 aspartate-semialdehyde dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0046983 protein dimerization activity
GO:0050661 NADP binding
GO:0051287 NAD binding

Biological Process:
GO:0006520 cellular amino acid metabolic process
GO:0008652 cellular amino acid biosynthetic process
GO:0009085 lysine biosynthetic process
GO:0009086 methionine biosynthetic process
GO:0009088 threonine biosynthetic process
GO:0009089 lysine biosynthetic process via diaminopimelate
GO:0009090 homoserine biosynthetic process
GO:0009097 isoleucine biosynthetic process
GO:0055114 oxidation-reduction process

Cellular Component:
GO:0005737 cytoplasm

-  Descriptions from all associated GenBank mRNAs

-  Other Names for This Gene
Protein: P13663 (aka DHAS_YEAST)

-  SGD Genes Methods, Credits, and Data Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.