S. cerevisiae Gene SAC3 (YDR159W)
  Description: Nuclear pore-associated protein required for biogenesis of the small ribosomal subunit component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay
Transcript (Including UTRs)
   Position: sacCer3 chrIV:771,877-775,782 Size: 3,906 Total Exon Count: 1 Strand: +
Coding Region
   Position: sacCer3 chrIV:771,877-775,782 Size: 3,906 Coding Exon Count: 1 

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mRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2011-08-29

-  Sequence and Links to Tools and Databases
Genomic Sequence (chrIV:771,877-775,782)mRNAProtein (1301 aa)
Gene SorterGenome BrowserOther Species FASTASGDUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Nuclear mRNA export protein SAC3; AltName: Full=Leucine permease transcriptional regulator;
FUNCTION: Component of the SAC3-THP1 complex, which functions in transcription-coupled mRNA export from the nucleus to the cytoplasm. SAC3-THP1 functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket), by association with components of the nuclear mRNA export machinery (MEX67-MTR2 and SUB2) in the nucleoplasm and the nucleoporin NUP1 at the nuclear basket.
SUBUNIT: Heterodimer with THP1. The SAC3-THP1 complex interacts with CDC31 and SUS1, and with the mRNA export factor MEX67-MTR2, the TREX complex component SUB2, and the nucleoporin NUP1. SAC3 directly interacts with MEX67, NUP1 and SUB2.
INTERACTION: P06704:CDC31; NbExp=10; IntAct=EBI-16425, EBI-4259; Q6WNK7:SUS1; NbExp=13; IntAct=EBI-16425, EBI-1251050; Q08231:THP1; NbExp=9; IntAct=EBI-16425, EBI-32097;
SUBCELLULAR LOCATION: Nucleus envelope. Note=Localizes to the nuclear pores.
MISCELLANEOUS: Present with 339 molecules/cell in log phase SD medium.
SIMILARITY: Belongs to the SAC3 family.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR024293 - CID_dom
IPR017173 - mRNA_export_fac_Sac3
IPR005062 - SAC3/GANP/Nin1/mts3/eIF-3-p25

Pfam Domains:
PF12209 - Leucine permease transcriptional regulator helical domain
PF03399 - SAC3/GANP family

Protein Data Bank (PDB) 3-D Structure
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- X-ray

ModBase Predicted Comparative 3D Structure on P46674
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanMouseRatZebrafishD. melanogasterC. elegans
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