S. cerevisiae Gene SIR4 (YDR227W)
  Description: Silent information regulator that, together with SIR2 and SIR3, is involved in assembly of silent chromatin domains at telomeres and the silent mating-type loci potentially phosphorylated by Cdc28p some alleles of SIR4 prolong lifespan
Transcript (Including UTRs)
   Position: sacCer3 chrIV:917,571-921,647 Size: 4,077 Total Exon Count: 1 Strand: +
Coding Region
   Position: sacCer3 chrIV:917,571-921,647 Size: 4,077 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsProtein StructureOther SpeciesGO Annotations
Other NamesMethods
Data last updated at UCSC: 2011-08-29

-  Sequence and Links to Tools and Databases
Genomic Sequence (chrIV:917,571-921,647)mRNAProtein (1358 aa)
Gene SorterGenome BrowserOther Species FASTASGDUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Regulatory protein SIR4; AltName: Full=Silent information regulator 4;
FUNCTION: The proteins SIR1 through SIR4 are required for transcriptional repression of the silent mating type loci, HML and HMR. The proteins SIR2 through SIR4 repress mulitple loci by modulating chromatin structure. Involves the compaction of chromatin fiber into a more condensed form.
SUBUNIT: Homodimer. Interacts with MPS3, RIS1, SIR1, SIR2, SIR3, YKU80 and RAP1 C-terminus.
INTERACTION: P11938:RAP1; NbExp=2; IntAct=EBI-17237, EBI-14821; P06700:SIR2; NbExp=7; IntAct=EBI-17237, EBI-17219; P06701:SIR3; NbExp=7; IntAct=EBI-17237, EBI-17230; Q04437:YKU80; NbExp=2; IntAct=EBI-17237, EBI-8224;

-  Protein Domain and Structure Information
  Protein Data Bank (PDB) 3-D Structure
MuPIT help

- X-ray

- X-ray

ModBase Predicted Comparative 3D Structure on P11978
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanMouseRatZebrafishD. melanogasterC. elegans
No orthologNo orthologNo orthologNo orthologGenome BrowserGenome Browser
    Gene DetailsGene Details
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    Protein SequenceProtein Sequence

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0005515 protein binding
GO:0031491 nucleosome binding
GO:0032947 protein complex scaffold

Biological Process:
GO:0001308 negative regulation of chromatin silencing involved in replicative cell aging
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006348 chromatin silencing at telomere
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0030466 chromatin silencing at silent mating-type cassette
GO:0031453 positive regulation of heterochromatin assembly
GO:0034398 telomere tethering at nuclear periphery
GO:0035389 establishment of chromatin silencing at silent mating-type cassette
GO:0097695 establishment of macromolecular complex localization to telomere
GO:0099114 chromatin silencing at subtelomere

Cellular Component:
GO:0000784 nuclear chromosome, telomeric region
GO:0005634 nucleus
GO:0005677 chromatin silencing complex
GO:0005724 nuclear telomeric heterochromatin
GO:0099115 chromosome, subtelomeric region

-  Other Names for This Gene
Protein: P11978 (aka SIR4_YEAST)

-  SGD Genes Methods, Credits, and Data Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.