Description: Silencing protein that interacts with Sir2p and Sir4p, and histone H3 and H4 tails, to establish a transcriptionally silent chromatin state required for spreading of silenced chromatin recruited to chromatin through interaction with Rap1p Transcript (Including UTRs) Position: sacCer3 chrXII:1,019,315-1,022,251 Size: 2,937 Total Exon Count: 1 Strand: - Coding Region Position: sacCer3 chrXII:1,019,315-1,022,251 Size: 2,937 Coding Exon Count: 1
ID:SIR3_YEAST DESCRIPTION: RecName: Full=Regulatory protein SIR3; AltName: Full=Silent information regulator 3; FUNCTION: The proteins SIR1 through SIR4 are required for transcriptional repression of the silent mating type loci, HML and HMR. The proteins SIR2 through SIR4 repress mulitple loci by modulating chromatin structure. Involves the compaction of chromatin fiber into a more condensed form. SUBUNIT: Homodimer and interacts with SIR4 and RAP1 C-terminus. Interacts with MCM10. INTERACTION: Self; NbExp=3; IntAct=EBI-17230, EBI-17230; P11938:RAP1; NbExp=2; IntAct=EBI-17230, EBI-14821; P11978:SIR4; NbExp=7; IntAct=EBI-17230, EBI-17237; SUBCELLULAR LOCATION: Nucleus. PTM: N-terminal acetylation by NatA is important for transcriptional silencing activity. MISCELLANEOUS: Present with 1400 molecules/cell in log phase SD medium. SIMILARITY: Contains 1 BAH domain.
ModBase Predicted Comparative 3D Structure on P06701
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary