S. cerevisiae Gene SIR3 (YLR442C)
  Description: Silencing protein that interacts with Sir2p and Sir4p, and histone H3 and H4 tails, to establish a transcriptionally silent chromatin state required for spreading of silenced chromatin recruited to chromatin through interaction with Rap1p
Transcript (Including UTRs)
   Position: sacCer3 chrXII:1,019,315-1,022,251 Size: 2,937 Total Exon Count: 1 Strand: -
Coding Region
   Position: sacCer3 chrXII:1,019,315-1,022,251 Size: 2,937 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsProtein StructureOther SpeciesGO Annotations
Other NamesMethods
Data last updated at UCSC: 2011-08-29

-  Sequence and Links to Tools and Databases
Genomic Sequence (chrXII:1,019,315-1,022,251)mRNAProtein (978 aa)
Gene SorterGenome BrowserOther Species FASTASGDUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Regulatory protein SIR3; AltName: Full=Silent information regulator 3;
FUNCTION: The proteins SIR1 through SIR4 are required for transcriptional repression of the silent mating type loci, HML and HMR. The proteins SIR2 through SIR4 repress mulitple loci by modulating chromatin structure. Involves the compaction of chromatin fiber into a more condensed form.
SUBUNIT: Homodimer and interacts with SIR4 and RAP1 C-terminus. Interacts with MCM10.
INTERACTION: Self; NbExp=3; IntAct=EBI-17230, EBI-17230; P11938:RAP1; NbExp=2; IntAct=EBI-17230, EBI-14821; P11978:SIR4; NbExp=7; IntAct=EBI-17230, EBI-17237;
PTM: N-terminal acetylation by NatA is important for transcriptional silencing activity.
MISCELLANEOUS: Present with 1400 molecules/cell in log phase SD medium.
SIMILARITY: Contains 1 BAH domain.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001025 - BAH_dom

Pfam Domains:
PF01426 - BAH domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help

- X-ray

- X-ray

- X-ray
To conserve bandwidth, only the images from the first 3 structures are shown.
3TE6 - X-ray 3TU4 - X-ray

ModBase Predicted Comparative 3D Structure on P06701
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanMouseRatZebrafishD. melanogasterC. elegans
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0003697 single-stranded DNA binding
GO:0005515 protein binding
GO:0031491 nucleosome binding
GO:0031493 nucleosomal histone binding
GO:0042802 identical protein binding

Biological Process:
GO:0001308 negative regulation of chromatin silencing involved in replicative cell aging
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006348 chromatin silencing at telomere
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0030466 chromatin silencing at silent mating-type cassette
GO:0031507 heterochromatin assembly
GO:0034398 telomere tethering at nuclear periphery
GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay
GO:0097695 establishment of macromolecular complex localization to telomere

Cellular Component:
GO:0000781 chromosome, telomeric region
GO:0000784 nuclear chromosome, telomeric region
GO:0005634 nucleus
GO:0005677 chromatin silencing complex
GO:0005720 nuclear heterochromatin
GO:0005724 nuclear telomeric heterochromatin
GO:0005730 nucleolus

-  Other Names for This Gene
Protein: P06701 (aka SIR3_YEAST)

-  SGD Genes Methods, Credits, and Data Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.