Human Gene MSH4 (ENST00000263187.4) from GENCODE V44
Description: Homo sapiens mutS homolog 4 (MSH4), mRNA. (from RefSeq NM_002440) RefSeq Summary (NM_002440): This gene encodes a member of the DNA mismatch repair mutS family. This member is a meiosis-specific protein that is not involved in DNA mismatch correction, but is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis I. This protein and MSH5 form a heterodimer which binds uniquely to a Holliday Junction and its developmental progenitor, thus provoking ADP-ATP exchange, and stabilizing the interaction between parental chromosomes during meiosis double-stranded break repair. [provided by RefSeq, Aug 2011]. Gencode Transcript: ENST00000263187.4 Gencode Gene: ENSG00000057468.7 Transcript (Including UTRs) Position: hg38 chr1:75,796,882-75,913,242 Size: 116,361 Total Exon Count: 20 Strand: + Coding Region Position: hg38 chr1:75,796,986-75,912,887 Size: 115,902 Coding Exon Count: 20
ID:MSH4_HUMAN DESCRIPTION: RecName: Full=MutS protein homolog 4; Short=hMSH4; FUNCTION: Involved in meiotic recombination. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis. SUBUNIT: Heterooligomer of MSH4 and MSH5. TISSUE SPECIFICITY: Testis and ovary specific. SIMILARITY: Belongs to the DNA mismatch repair MutS family. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/msh4/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF05188 - MutS domain II PF05192 - MutS domain III PF05190 - MutS family domain IV PF00488 - MutS domain V
ModBase Predicted Comparative 3D Structure on O15457
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.