Human Gene ARHGEF16 (ENST00000378378.9) from GENCODE V44
Description: Homo sapiens Rho guanine nucleotide exchange factor 16 (ARHGEF16), mRNA. (from RefSeq NM_014448) RefSeq Summary (NM_014448): Although the specific function of this protein is not known yet, it is thought to be involved in protein-protein and protein-lipid interactions. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000378378.9 Gencode Gene: ENSG00000130762.15 Transcript (Including UTRs) Position: hg38 chr1:3,454,665-3,481,113 Size: 26,449 Total Exon Count: 15 Strand: + Coding Region Position: hg38 chr1:3,463,085-3,480,587 Size: 17,503 Coding Exon Count: 14
ID:ARHGG_HUMAN DESCRIPTION: RecName: Full=Rho guanine nucleotide exchange factor 16; AltName: Full=Ephexin-4; FUNCTION: Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6. SUBUNIT: Interacts with ELMO2, EPHA2, RAC1 and RHOG; mediates activation of RAC1 by EPHA2. Interacts with TAX1BP3 (via PDZ domain). May interact with CDC42; stimulated by HPV16 E6. SUBCELLULAR LOCATION: Cytoplasm (Probable). INDUCTION: Up-regulated by HPV16 E6 (at protein level). DOMAIN: The PDZ-binding motif mediates interaction with TAX1BP3. SIMILARITY: Contains 1 DH (DBL-homology) domain. SIMILARITY: Contains 1 PH domain. SIMILARITY: Contains 1 SH3 domain. SEQUENCE CAUTION: Sequence=AAH02681.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q5VV41
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0007186 G-protein coupled receptor signaling pathway GO:0035023 regulation of Rho protein signal transduction GO:0043065 positive regulation of apoptotic process GO:0051056 regulation of small GTPase mediated signal transduction GO:0060326 cell chemotaxis GO:0090630 activation of GTPase activity GO:1903078 positive regulation of protein localization to plasma membrane
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