Human Gene SLC2A5 (ENST00000377424.9) from GENCODE V44
Description: Homo sapiens solute carrier family 2 member 5 (SLC2A5), transcript variant 1, mRNA. (from RefSeq NM_003039) RefSeq Summary (NM_003039): The protein encoded by this gene is a fructose transporter responsible for fructose uptake by the small intestine. The encoded protein also is necessary for the increase in blood pressure due to high dietary fructose consumption. [provided by RefSeq, Jun 2016]. Gencode Transcript: ENST00000377424.9 Gencode Gene: ENSG00000142583.18 Transcript (Including UTRs) Position: hg38 chr1:9,035,106-9,069,635 Size: 34,530 Total Exon Count: 12 Strand: - Coding Region Position: hg38 chr1:9,037,586-9,069,536 Size: 31,951 Coding Exon Count: 12
ID:GTR5_HUMAN DESCRIPTION: RecName: Full=Solute carrier family 2, facilitated glucose transporter member 5; AltName: Full=Fructose transporter; AltName: Full=Glucose transporter type 5, small intestine; Short=GLUT-5; FUNCTION: Cytochalasin B-sensitive carrier. Seems to function primarily as a fructose transporter. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in small intestine, and at much lower levels in kidney, skeletal muscle, and adipose tissue. INDUCTION: By forskolin in Caco-2 cells. MASS SPECTROMETRY: Mass=54973.98; Method=MALDI; Range=1-501; Source=PubMed:11840567; SIMILARITY: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. SEQUENCE CAUTION: Sequence=AAB60641.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P22732
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal GO:0005975 carbohydrate metabolic process GO:0008643 carbohydrate transport GO:0009750 response to fructose GO:0015755 fructose transport GO:0043312 neutrophil degranulation GO:0055085 transmembrane transport GO:0071332 cellular response to fructose stimulus GO:1904659 glucose transmembrane transport GO:1990539 fructose import across plasma membrane
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Sequence and Links to Tools and Databases 
Microarray Expression Data 
