Human Gene AGTRAP (ENST00000314340.10) from GENCODE V44
Description: Homo sapiens angiotensin II receptor associated protein (AGTRAP), transcript variant 1, mRNA. (from RefSeq NM_020350) RefSeq Summary (NM_020350): This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000314340.10 Gencode Gene: ENSG00000177674.16 Transcript (Including UTRs) Position: hg38 chr1:11,736,136-11,750,769 Size: 14,634 Total Exon Count: 5 Strand: + Coding Region Position: hg38 chr1:11,736,209-11,750,192 Size: 13,984 Coding Exon Count: 5
ID:ATRAP_HUMAN DESCRIPTION: RecName: Full=Type-1 angiotensin II receptor-associated protein; AltName: Full=AT1 receptor-associated protein; FUNCTION: Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity. SUBUNIT: Interacts with GNB2L1/RACK1, and with the C-terminal region of AGTR1. INTERACTION: Q96AL5:PBX3; NbExp=3; IntAct=EBI-741181, EBI-741171; Q9UKF7:PITPNC1; NbExp=3; IntAct=EBI-741181, EBI-749241; SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles. TISSUE SPECIFICITY: Ubiquitous but more abundant in kidney, heart, pancreas and thyroid. SEQUENCE CAUTION: Sequence=CAI15876.1; Type=Erroneous gene model prediction; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/agtrap/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF06396 - Angiotensin II, type I receptor-associated protein (AGTRAP)
ModBase Predicted Comparative 3D Structure on Q6RW13
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK290042 - Homo sapiens cDNA FLJ75423 complete cds, highly similar to Homo sapiens angiotensin II receptor-associated protein (AGTRAP), mRNA. BC017328 - Homo sapiens angiotensin II receptor-associated protein, mRNA (cDNA clone MGC:29646 IMAGE:4546585), complete cds. AF312374 - Homo sapiens AGTRAP protein mRNA, complete cds. E09415 - cDNA encoding a polypeptide obtained from human gliablastoma cells. BC011946 - Homo sapiens cDNA clone IMAGE:3857985. JD422171 - Sequence 403195 from Patent EP1572962. KJ899301 - Synthetic construct Homo sapiens clone ccsbBroadEn_08695 AGTRAP gene, encodes complete protein. AB528670 - Synthetic construct DNA, clone: pF1KB6809, Homo sapiens AGTRAP gene for angiotensin II receptor-associated protein, without stop codon, in Flexi system. DQ892619 - Synthetic construct clone IMAGE:100005249; FLH188371.01X; RZPDo839B0873D angiotensin II receptor-associated protein (AGTRAP) gene, encodes complete protein. DQ895859 - Synthetic construct Homo sapiens clone IMAGE:100010319; FLH188367.01L; RZPDo839B0863D angiotensin II receptor-associated protein (AGTRAP) gene, encodes complete protein. AF165187 - Homo sapiens ATRAP mRNA, complete cds. E09414 - cDNA encoding a polypeptide obtained from human gliablastoma cells. JD384878 - Sequence 365902 from Patent EP1572962. JD308068 - Sequence 289092 from Patent EP1572962. JD108561 - Sequence 89585 from Patent EP1572962. JD274753 - Sequence 255777 from Patent EP1572962. JD292280 - Sequence 273304 from Patent EP1572962. JD158671 - Sequence 139695 from Patent EP1572962. JD521584 - Sequence 502608 from Patent EP1572962. JD289873 - Sequence 270897 from Patent EP1572962. JD486986 - Sequence 468010 from Patent EP1572962. JD146271 - Sequence 127295 from Patent EP1572962. JD449352 - Sequence 430376 from Patent EP1572962. JD218386 - Sequence 199410 from Patent EP1572962. JD344358 - Sequence 325382 from Patent EP1572962. JD162137 - Sequence 143161 from Patent EP1572962. JD364105 - Sequence 345129 from Patent EP1572962. JD096856 - Sequence 77880 from Patent EP1572962. JD460281 - Sequence 441305 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q6RW13 (Reactome details) participates in the following event(s):
R-HSA-6802927 BRAF and RAF fusion mutant dimers are phosphorylated R-HSA-6802934 p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs R-HSA-6802932 Dissociation of BRAF/RAF fusion complex R-HSA-6802933 p-BRAF and RAF fusion dimers phosphorylate MAP2Ks R-HSA-6802935 MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers R-HSA-6802952 Signaling by BRAF and RAF fusions R-HSA-6802957 Oncogenic MAPK signaling R-HSA-5663202 Diseases of signal transduction R-HSA-1643685 Disease
US Server
