Human Gene PRKACB (ENST00000370685.7) from GENCODE V43
  Description: Homo sapiens protein kinase cAMP-activated catalytic subunit beta (PRKACB), transcript variant 1, mRNA. (from RefSeq NM_182948)
RefSeq Summary (NM_182948): The protein encoded by this gene is a member of the serine/threonine protein kinase family. The encoded protein is a catalytic subunit of cAMP (cyclic AMP)-dependent protein kinase, which mediates signalling though cAMP. cAMP signaling is important to a number of processes, including cell proliferaton and differentiation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2014].
Gencode Transcript: ENST00000370685.7
Gencode Gene: ENSG00000142875.20
Transcript (Including UTRs)
   Position: hg38 chr1:84,144,271-84,238,498 Size: 94,228 Total Exon Count: 10 Strand: +
Coding Region
   Position: hg38 chr1:84,144,362-84,235,305 Size: 90,944 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesMethods
Data last updated at UCSC: 2023-02-17 13:02:02

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:84,144,271-84,238,498)mRNA (may differ from genome)Protein (398 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=cAMP-dependent protein kinase catalytic subunit beta; Short=PKA C-beta; EC=;
FUNCTION: Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis.
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
COFACTOR: Magnesium.
SUBUNIT: A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. The cAMP-dependent protein kinase catalytic subunit binds PJA2 (By similarity).
INTERACTION: Q92917:GPKOW; NbExp=4; IntAct=EBI-5258763, EBI-746309;
SUBCELLULAR LOCATION: Cytoplasm. Cell membrane. Nucleus (By similarity). Note=Translocates into the nucleus (monomeric catalytic subunit) (By similarity). The inactive holoenzyme is found in the cytoplasm (By similarity).
TISSUE SPECIFICITY: Isoform 1 is most abundant in the brain, with low level expression in kidney. Isoform 2 is predominantly expressed in thymus, spleen and kidney. Isoform 3 and isoform 4 are only expressed in the brain.
PTM: Asn-3 is partially deaminated to Asp giving rise to 2 major isoelectric variants, called CB and CA respectively (By similarity).
SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
SIMILARITY: Contains 1 AGC-kinase C-terminal domain.
SIMILARITY: Contains 1 protein kinase domain.
SEQUENCE CAUTION: Sequence=BAD92426.1; Type=Frameshift; Positions=322;
WEB RESOURCE: Name=SeattleSNPs; URL="";

-  Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

-  MalaCards Disease Associations
  MalaCards Gene Search: PRKACB
Diseases sorted by gene-association score: carney complex variant (5)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 55.12 RPKM in Brain - Frontal Cortex (BA9)
Total median expression: 690.71 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -29.6091-0.325 Picture PostScript Text
3' UTR -741.903193-0.232 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000961 - AGC-kinase_C
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR002290 - Ser/Thr_dual-sp_kinase_dom
IPR008271 - Ser/Thr_kinase_AS

Pfam Domains:
PF00069 - Protein kinase domain

ModBase Predicted Comparative 3D Structure on P22694
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein SequenceProtein Sequence   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004691 cAMP-dependent protein kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0031625 ubiquitin protein ligase binding

Biological Process:
GO:0001843 neural tube closure
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0003091 renal water homeostasis
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007596 blood coagulation
GO:0016310 phosphorylation
GO:0034199 activation of protein kinase A activity
GO:0034380 high-density lipoprotein particle assembly
GO:0051447 negative regulation of meiotic cell cycle
GO:0070613 regulation of protein processing
GO:0071377 cellular response to glucagon stimulus
GO:0097338 response to clozapine
GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005952 cAMP-dependent protein kinase complex
GO:0016020 membrane
GO:0045171 intercellular bridge
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular exosome
GO:0097546 ciliary base

-  Descriptions from all associated GenBank mRNAs
  LF206366 - JP 2014500723-A/13869: Polycomb-Associated Non-Coding RNAs.
MA441943 - JP 2018138019-A/13869: Polycomb-Associated Non-Coding RNAs.
BC035058 - Homo sapiens protein kinase, cAMP-dependent, catalytic, beta, mRNA (cDNA clone MGC:41879 IMAGE:5262372), complete cds.
AK314550 - Homo sapiens cDNA, FLJ95374, Homo sapiens protein kinase, cAMP-dependent, catalytic, beta(PRKACB), transcript variant 2, mRNA.
BC016285 - Homo sapiens protein kinase, cAMP-dependent, catalytic, beta, mRNA (cDNA clone MGC:9320 IMAGE:3916100), complete cds.
M34181 - Human testis-specific cAMP-dependent protein kinase catalytic subunit (C-beta isoform) mRNA, complete cds.
CU677593 - Synthetic construct Homo sapiens gateway clone IMAGE:100018627 5' read PRKACB mRNA.
AB463197 - Synthetic construct DNA, clone: pF1KB8430, Homo sapiens PRKACB gene for protein kinase, cAMP-dependent, catalytic, beta, without stop codon, in Flexi system.
AM392526 - Synthetic construct Homo sapiens clone IMAGE:100002647 for hypothetical protein (PRKACB gene).
AM393233 - Synthetic construct Homo sapiens clone IMAGE:100002909 for hypothetical protein (PRKACB gene).
AM393317 - Synthetic construct Homo sapiens clone IMAGE:100002648 for hypothetical protein (PRKACB gene).
AM393497 - Synthetic construct Homo sapiens clone IMAGE:100002649 for hypothetical protein (PRKACB gene).
KJ891884 - Synthetic construct Homo sapiens clone ccsbBroadEn_01278 PRKACB gene, encodes complete protein.
EU832783 - Synthetic construct Homo sapiens clone HAIB:100067812; DKFZo008C0233 protein kinase, cAMP-dependent, catalytic, beta protein (PRKACB) gene, encodes complete protein.
GQ129404 - Synthetic construct Homo sapiens clone HAIB:100068472; DKFZo004C0234 protein kinase, cAMP-dependent, catalytic, beta protein (PRKACB) gene, partial cds.
KJ897377 - Synthetic construct Homo sapiens clone ccsbBroadEn_06771 PRKACB gene, encodes complete protein.
KJ905281 - Synthetic construct Homo sapiens clone ccsbBroadEn_14781 PRKACB gene, encodes complete protein.
AB451364 - Homo sapiens PRKACB mRNA for cAMP-dependent protein kinase catalytic subunit beta isoform 2, partial cds, clone: FLJ08037AAAF.
AB451239 - Homo sapiens PRKACB mRNA for cAMP-dependent protein kinase catalytic subunit beta isoform 2, complete cds, clone: FLJ08037AAAN.
BX537705 - Homo sapiens mRNA; cDNA DKFZp686H10244 (from clone DKFZp686H10244).
BX641026 - Homo sapiens mRNA; cDNA DKFZp686K18247 (from clone DKFZp686K18247).
AY927364 - Homo sapiens cAMP-dependent protein kinase catalytic beta subunit isoform 2 (PRKACB) mRNA, partial cds, alternatively spliced.
AK304322 - Homo sapiens cDNA FLJ54730 complete cds, highly similar to cAMP-dependent protein kinase, beta-2-catalytic subunit (EC
EU832837 - Synthetic construct Homo sapiens clone HAIB:100067866; DKFZo008H0133 protein kinase, cAMP-dependent, catalytic, beta protein (PRKACB) gene, encodes complete protein.
GQ129233 - Synthetic construct Homo sapiens clone HAIB:100068528; DKFZo004H0134 protein kinase, cAMP-dependent, catalytic, beta protein (PRKACB) gene, partial cds.
AY927365 - Homo sapiens cAMP-dependent protein kinase catalytic beta subunit isoform 3 (PRKACB) mRNA, partial cds, alternatively spliced.
AK296482 - Homo sapiens cDNA FLJ52554 complete cds, highly similar to cAMP-dependent protein kinase, beta-catalytic subunit (EC
AK304375 - Homo sapiens cDNA FLJ54579 complete cds, highly similar to cAMP-dependent protein kinase, beta-catalytic subunit (EC
CR936631 - Homo sapiens mRNA; cDNA DKFZp781I2452 (from clone DKFZp781I2452).
BX647515 - Homo sapiens mRNA; cDNA DKFZp686G17199 (from clone DKFZp686G17199).
AB209189 - Homo sapiens mRNA for cAMP-dependent protein kinase catalytic subunit beta isoform 2 variant protein.
AY927366 - Homo sapiens cAMP-dependent protein kinase catalytic beta subunit isoform 4 (PRKACB) mRNA, partial cds, alternatively spliced.
AY927367 - Homo sapiens cAMP-dependent protein kinase catalytic beta subunit isoform 4ab (PRKACB) mRNA, partial cds, alternatively spliced.
AY927368 - Homo sapiens cAMP-dependent protein kinase catalytic beta subunit isoform 4abc (PRKACB) mRNA, partial cds, alternatively spliced.
AK091420 - Homo sapiens cDNA FLJ34101 fis, clone FCBBF3007631, highly similar to cAMP-dependent protein kinase, beta-catalytic subunit (EC
AX746972 - Sequence 497 from Patent EP1308459.
GQ129231 - Synthetic construct Homo sapiens clone HAIB:100068526; DKFZo004G1134 protein kinase, cAMP-dependent, catalytic, beta protein (PRKACB) gene, partial cds.
EU832835 - Synthetic construct Homo sapiens clone HAIB:100067864; DKFZo008G1133 protein kinase, cAMP-dependent, catalytic, beta protein (PRKACB) gene, encodes complete protein.
EU832842 - Synthetic construct Homo sapiens clone HAIB:100067871; DKFZo008H0633 protein kinase, cAMP-dependent, catalytic, beta protein (PRKACB) gene, encodes complete protein.
GQ129248 - Synthetic construct Homo sapiens clone HAIB:100068533; DKFZo004H0634 protein kinase, cAMP-dependent, catalytic, beta protein (PRKACB) gene, partial cds.
AK316115 - Homo sapiens cDNA, FLJ79014 complete cds, highly similar to cAMP-dependent protein kinase, beta-catalytic subunit (EC
LF353572 - JP 2014500723-A/161075: Polycomb-Associated Non-Coding RNAs.
MA589149 - JP 2018138019-A/161075: Polycomb-Associated Non-Coding RNAs.
LF353568 - JP 2014500723-A/161071: Polycomb-Associated Non-Coding RNAs.
MA589145 - JP 2018138019-A/161071: Polycomb-Associated Non-Coding RNAs.
LF353560 - JP 2014500723-A/161063: Polycomb-Associated Non-Coding RNAs.
MA589137 - JP 2018138019-A/161063: Polycomb-Associated Non-Coding RNAs.
LF353559 - JP 2014500723-A/161062: Polycomb-Associated Non-Coding RNAs.
MA589136 - JP 2018138019-A/161062: Polycomb-Associated Non-Coding RNAs.
JD548472 - Sequence 529496 from Patent EP1572962.
JD259982 - Sequence 241006 from Patent EP1572962.
JD221129 - Sequence 202153 from Patent EP1572962.
JD548659 - Sequence 529683 from Patent EP1572962.
JD303589 - Sequence 284613 from Patent EP1572962.
JD235464 - Sequence 216488 from Patent EP1572962.
JD291822 - Sequence 272846 from Patent EP1572962.
JD266656 - Sequence 247680 from Patent EP1572962.
LF353558 - JP 2014500723-A/161061: Polycomb-Associated Non-Coding RNAs.
MA589135 - JP 2018138019-A/161061: Polycomb-Associated Non-Coding RNAs.
JD345204 - Sequence 326228 from Patent EP1572962.
JD559921 - Sequence 540945 from Patent EP1572962.
JD391929 - Sequence 372953 from Patent EP1572962.
JD170937 - Sequence 151961 from Patent EP1572962.
LF353557 - JP 2014500723-A/161060: Polycomb-Associated Non-Coding RNAs.
MA589134 - JP 2018138019-A/161060: Polycomb-Associated Non-Coding RNAs.
JD490118 - Sequence 471142 from Patent EP1572962.
JD562332 - Sequence 543356 from Patent EP1572962.
JD146761 - Sequence 127785 from Patent EP1572962.
JD474142 - Sequence 455166 from Patent EP1572962.
JD199851 - Sequence 180875 from Patent EP1572962.
JD083096 - Sequence 64120 from Patent EP1572962.
JD528103 - Sequence 509127 from Patent EP1572962.
JD314298 - Sequence 295322 from Patent EP1572962.
JD353299 - Sequence 334323 from Patent EP1572962.
JD259546 - Sequence 240570 from Patent EP1572962.
LF353556 - JP 2014500723-A/161059: Polycomb-Associated Non-Coding RNAs.
MA589133 - JP 2018138019-A/161059: Polycomb-Associated Non-Coding RNAs.
JD509228 - Sequence 490252 from Patent EP1572962.
JD242327 - Sequence 223351 from Patent EP1572962.
JD433117 - Sequence 414141 from Patent EP1572962.
JD288411 - Sequence 269435 from Patent EP1572962.
LF353555 - JP 2014500723-A/161058: Polycomb-Associated Non-Coding RNAs.
MA589132 - JP 2018138019-A/161058: Polycomb-Associated Non-Coding RNAs.
AL050208 - Homo sapiens mRNA; cDNA DKFZp586F2323 (from clone DKFZp586F2323).

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04010 - MAPK signaling pathway
hsa04020 - Calcium signaling pathway
hsa04062 - Chemokine signaling pathway
hsa04114 - Oocyte meiosis
hsa04210 - Apoptosis
hsa04270 - Vascular smooth muscle contraction
hsa04310 - Wnt signaling pathway
hsa04340 - Hedgehog signaling pathway
hsa04540 - Gap junction
hsa04720 - Long-term potentiation
hsa04740 - Olfactory transduction
hsa04742 - Taste transduction
hsa04910 - Insulin signaling pathway
hsa04912 - GnRH signaling pathway
hsa04914 - Progesterone-mediated oocyte maturation
hsa04916 - Melanogenesis
hsa04962 - Vasopressin-regulated water reabsorption
hsa05020 - Prion diseases
hsa05110 - Vibrio cholerae infection
hsa05414 - Dilated cardiomyopathy

BioCarta from NCI Cancer Genome Anatomy Project
h_nfatPathway - NFAT and Hypertrophy of the heart (Transcription in the broken heart)
h_gpcrPathway - Signaling Pathway from G-Protein Families
h_mPRPathway - How Progesterone Initiates the Oocyte Maturation
h_dreampathway - Repression of Pain Sensation by the Transcriptional Regulator DREAM
h_mCalpainPathway - mCalpain and friends in Cell motility
h_plcePathway - Phospholipase C-epsilon pathway
h_stathminPathway - Stathmin and breast cancer resistance to antimicrotubule agents
h_akap95Pathway - AKAP95 role in mitosis and chromosome dynamics
h_agpcrPathway - Attenuation of GPCR Signaling
h_crebPathway - Transcription factor CREB and its extracellular signals
h_pparaPathway - Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)
h_akapCentrosomePathway - Protein Kinase A at the Centrosome
h_badPathway - Regulation of BAD phosphorylation
h_CSKPathway - Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor
h_cftrPathway - Cystic fibrosis transmembrane conductance regulator (CFTR) and beta 2 adrenergic receptor (b2AR) pathway
h_ck1Pathway - Regulation of ck1/cdk5 by type 1 glutamate receptors
h_igf1rPathway - Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation
h_shhPathway - Sonic Hedgehog (Shh) Pathway
h_chrebpPathway - ChREBP regulation by carbohydrates and cAMP
h_no1Pathway - Actions of Nitric Oxide in the Heart
h_akap13Pathway - Rho-Selective Guanine Exchange Factor AKAP13 Mediates Stress Fiber Formation
h_GATA3pathway - GATA3 participate in activating the Th2 cytokine genes expression
h_carm1Pathway - Transcription Regulation by Methyltransferase of CARM1
h_nos1Pathway - Nitric Oxide Signaling Pathway
h_vipPathway - Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells

Reactome (by CSHL, EBI, and GO)

Protein P22694 (Reactome details) participates in the following event(s):

R-HSA-111924 PKA catalytic subunit translocates to the nucleus
R-HSA-111925 cAMP induces dissociation of inactive PKA tetramers
R-HSA-381707 PKA:AKAP79:IQGAP1 complex dissociates to active PKA subunits in response to cAMP
R-HSA-5610749 cAMP dissociates PKA, promoting GLI processing
R-HSA-992708 Dual-specific AKAPs bind type I and II PKA regulatory subunits
R-HSA-8951727 cAMP binds PKA tetramer
R-HSA-9010641 AKAP5 recruits PKA to ROBO2
R-HSA-163416 hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP
R-HSA-163418 perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP
R-HSA-5682101 PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer
R-HSA-163676 Phosphorylation of pChREBP (Thr 666) at Ser(196) by PKA
R-HSA-163773 Phosphorylation of PF2K-Pase by PKA catalytic subunit
R-HSA-432232 Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA)
R-HSA-177275 PKA phosphorylates DARPP-32 on Thr34
R-HSA-177284 PKA phosphorylates PDE4B
R-HSA-5218854 p-Y420-FYN is phosphorylated on S21
R-HSA-8854908 PKA phosphorylates RET:GDNF:GFRA dimer
R-HSA-111919 PKA phosphorylates CREB
R-HSA-163672 Phosphorylation of ChREBP at Thr(666) by PKA
R-HSA-5687088 PKA phosphorylates MAPKAPK5
R-HSA-443474 Phosphorylation of CREB by PKA
R-HSA-5610717 PKA phosphorylates GLI2
R-HSA-5610720 PKA phosphorylates GLI3
R-HSA-5610741 PKA phosphorylates GLI1
R-HSA-913996 PKA/PKG phosphorylate Rap1GAP2
R-HSA-5624473 Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit
R-HSA-111931 PKA-mediated phosphorylation of CREB
R-HSA-163615 PKA activation
R-HSA-164378 PKA activation in glucagon signalling
R-HSA-180024 DARPP-32 events
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-5610787 Hedgehog 'off' state
R-HSA-983231 Factors involved in megakaryocyte development and platelet production
R-HSA-9010642 ROBO receptors bind AKAP5
R-HSA-111933 Calmodulin induced events
R-HSA-163359 Glucagon signaling in metabolic regulation
R-HSA-111885 Opioid Signalling
R-HSA-445717 Aquaporin-mediated transport
R-HSA-422356 Regulation of insulin secretion
R-HSA-163560 Triglyceride catabolism
R-HSA-8963896 HDL assembly
R-HSA-163358 PKA-mediated phosphorylation of key metabolic factors
R-HSA-70171 Glycolysis
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-8853659 RET signaling
R-HSA-5687128 MAPK6/MAPK4 signaling
R-HSA-442720 CREB phosphorylation through the activation of Adenylate Cyclase
R-HSA-5358351 Signaling by Hedgehog
R-HSA-5610783 Degradation of GLI2 by the proteasome
R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome
R-HSA-5610780 Degradation of GLI1 by the proteasome
R-HSA-109582 Hemostasis
R-HSA-376176 Signaling by ROBO receptors
R-HSA-111997 CaM pathway
R-HSA-163685 Energy Metabolism
R-HSA-418594 G alpha (i) signalling events
R-HSA-382551 Transport of small molecules
R-HSA-8979227 Triglyceride metabolism
R-HSA-8963898 Plasma lipoprotein assembly
R-HSA-70326 Glucose metabolism
R-HSA-392517 Rap1 signalling
R-HSA-194138 Signaling by VEGF
R-HSA-422475 Axon guidance
R-HSA-5621575 CD209 (DC-SIGN) signaling
R-HSA-5683057 MAPK family signaling cascades
R-HSA-438064 Post NMDA receptor activation events
R-HSA-162582 Signal Transduction
R-HSA-111996 Ca-dependent events
R-HSA-1489509 DAG and IP3 signaling
R-HSA-1430728 Metabolism
R-HSA-388396 GPCR downstream signalling
R-HSA-556833 Metabolism of lipids
R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance
R-HSA-71387 Metabolism of carbohydrates
R-HSA-1280218 Adaptive Immune System
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-1266738 Developmental Biology
R-HSA-5621481 C-type lectin receptors (CLRs)
R-HSA-442755 Activation of NMDA receptor and postsynaptic events
R-HSA-112043 PLC beta mediated events
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-372790 Signaling by GPCR
R-HSA-168256 Immune System
R-HSA-168249 Innate Immune System
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112040 G-protein mediated events
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System

-  Other Names for This Gene
  Alternate Gene Symbols: B4DKB0, B4E2Q1, ENST00000370685.1, ENST00000370685.2, ENST00000370685.3, ENST00000370685.4, ENST00000370685.5, ENST00000370685.6, KAPCB_HUMAN, NM_182948, P22694, Q14VH1, Q59GC0, Q5BNE9, Q5BNF0, Q5BNF1, Q5BNF2, Q5BNF3, Q5CZ92, Q5T1K3, Q7Z3M1, Q8IYR5, Q8IZQ0, Q96B09, uc001djl.1, uc001djl.2, uc001djl.3, uc001djl.4
UCSC ID: ENST00000370685.7
RefSeq Accession: NM_182948
Protein: P22694 (aka KAPCB_HUMAN)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.