Human Gene PRKACB (ENST00000370685.7) from GENCODE V43
Description: Homo sapiens protein kinase cAMP-activated catalytic subunit beta (PRKACB), transcript variant 1, mRNA. (from RefSeq NM_182948) RefSeq Summary (NM_182948): The protein encoded by this gene is a member of the serine/threonine protein kinase family. The encoded protein is a catalytic subunit of cAMP (cyclic AMP)-dependent protein kinase, which mediates signalling though cAMP. cAMP signaling is important to a number of processes, including cell proliferaton and differentiation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2014]. Gencode Transcript: ENST00000370685.7 Gencode Gene: ENSG00000142875.20 Transcript (Including UTRs) Position: hg38 chr1:84,144,271-84,238,498 Size: 94,228 Total Exon Count: 10 Strand: + Coding Region Position: hg38 chr1:84,144,362-84,235,305 Size: 90,944 Coding Exon Count: 10
ID:KAPCB_HUMAN DESCRIPTION: RecName: Full=cAMP-dependent protein kinase catalytic subunit beta; Short=PKA C-beta; EC=2.7.11.11; FUNCTION: Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. COFACTOR: Magnesium. ENZYME REGULATION: Activated by cAMP. SUBUNIT: A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. The cAMP-dependent protein kinase catalytic subunit binds PJA2 (By similarity). INTERACTION: Q92917:GPKOW; NbExp=4; IntAct=EBI-5258763, EBI-746309; SUBCELLULAR LOCATION: Cytoplasm. Cell membrane. Nucleus (By similarity). Note=Translocates into the nucleus (monomeric catalytic subunit) (By similarity). The inactive holoenzyme is found in the cytoplasm (By similarity). TISSUE SPECIFICITY: Isoform 1 is most abundant in the brain, with low level expression in kidney. Isoform 2 is predominantly expressed in thymus, spleen and kidney. Isoform 3 and isoform 4 are only expressed in the brain. PTM: Asn-3 is partially deaminated to Asp giving rise to 2 major isoelectric variants, called CB and CA respectively (By similarity). SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. SIMILARITY: Contains 1 AGC-kinase C-terminal domain. SIMILARITY: Contains 1 protein kinase domain. SEQUENCE CAUTION: Sequence=BAD92426.1; Type=Frameshift; Positions=322; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/prkacb/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P22694
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BioCarta from NCI Cancer Genome Anatomy Project h_nfatPathway - NFAT and Hypertrophy of the heart (Transcription in the broken heart) h_gpcrPathway - Signaling Pathway from G-Protein Families h_mPRPathway - How Progesterone Initiates the Oocyte Maturation h_dreampathway - Repression of Pain Sensation by the Transcriptional Regulator DREAM h_mCalpainPathway - mCalpain and friends in Cell motility h_plcePathway - Phospholipase C-epsilon pathway h_stathminPathway - Stathmin and breast cancer resistance to antimicrotubule agents h_akap95Pathway - AKAP95 role in mitosis and chromosome dynamics h_agpcrPathway - Attenuation of GPCR Signaling h_crebPathway - Transcription factor CREB and its extracellular signals h_pparaPathway - Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) h_akapCentrosomePathway - Protein Kinase A at the Centrosome h_badPathway - Regulation of BAD phosphorylation h_CSKPathway - Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor h_cftrPathway - Cystic fibrosis transmembrane conductance regulator (CFTR) and beta 2 adrenergic receptor (b2AR) pathway h_ck1Pathway - Regulation of ck1/cdk5 by type 1 glutamate receptors h_igf1rPathway - Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation h_shhPathway - Sonic Hedgehog (Shh) Pathway h_chrebpPathway - ChREBP regulation by carbohydrates and cAMP h_no1Pathway - Actions of Nitric Oxide in the Heart h_akap13Pathway - Rho-Selective Guanine Exchange Factor AKAP13 Mediates Stress Fiber Formation h_GATA3pathway - GATA3 participate in activating the Th2 cytokine genes expression h_carm1Pathway - Transcription Regulation by Methyltransferase of CARM1 h_nos1Pathway - Nitric Oxide Signaling Pathway h_vipPathway - Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells
Reactome (by CSHL, EBI, and GO)
Protein P22694 (Reactome details) participates in the following event(s):
US Server
