Human Gene PROK1 (ENST00000271331.4) from GENCODE V44
Description: Homo sapiens prokineticin 1 (PROK1), mRNA. (from RefSeq NM_032414) RefSeq Summary (NM_032414): The protein encoded by this gene induces proliferation, migration, and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. It has little or no effect on a variety of other endothelial and non-endothelial cell types. Its expression is restricted to the steroidogenic glands (ovary, testis, adrenal, and placenta), is induced by hypoxia, and often complementary to the expression of vascular endothelial growth factor (VEGF), suggesting that these molecules function in a coordinated manner. [provided by RefSeq, Sep 2011]. Gencode Transcript: ENST00000271331.4 Gencode Gene: ENSG00000143125.6 Transcript (Including UTRs) Position: hg38 chr1:110,451,149-110,457,358 Size: 6,210 Total Exon Count: 3 Strand: + Coding Region Position: hg38 chr1:110,451,217-110,456,351 Size: 5,135 Coding Exon Count: 3
ID:PROK1_HUMAN DESCRIPTION: RecName: Full=Prokineticin-1; AltName: Full=Endocrine-gland-derived vascular endothelial growth factor; Short=EG-VEGF; AltName: Full=Mambakine; Flags: Precursor; FUNCTION: Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. Has little or no effect on a variety of other endothelial and non-endothelial cell types. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. May play a role in placentation. May play a role in normal and pathological testis angiogenesis. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Localizes to glandular epithelium, stroma and vascular epithelial cells of first trimester decidua (at protein level). Up-regulated in first trimester decidua when compared with non-pregnant endometrium. Expressed in the steroidogenic glands, ovary, testis, adrenal and placenta. DEVELOPMENTAL STAGE: In adult testis, is strongly expressed only in Leydig cells. In testicular tumors, expressed specifically in Leydig cell tumors (at protein level). Expressed from 14 weeks until birth in fetal testis. SIMILARITY: Belongs to the AVIT (prokineticin) family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P58294
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.