Human Gene PTGFRN (ENST00000393203.3) from GENCODE V44
  Description: Homo sapiens prostaglandin F2 receptor inhibitor (PTGFRN), mRNA. (from RefSeq NM_020440)
Gencode Transcript: ENST00000393203.3
Gencode Gene: ENSG00000134247.10
Transcript (Including UTRs)
   Position: hg38 chr1:116,909,916-116,990,353 Size: 80,438 Total Exon Count: 9 Strand: +
Coding Region
   Position: hg38 chr1:116,910,204-116,986,967 Size: 76,764 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:116,909,916-116,990,353)mRNA (may differ from genome)Protein (879 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
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HGNCHPRDLynxMGIneXtProtOMIM
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-  Comments and Description Text from UniProtKB
  ID: FPRP_HUMAN
DESCRIPTION: RecName: Full=Prostaglandin F2 receptor negative regulator; AltName: Full=CD9 partner 1; Short=CD9P-1; AltName: Full=Glu-Trp-Ile EWI motif-containing protein F; Short=EWI-F; AltName: Full=Prostaglandin F2-alpha receptor regulatory protein; AltName: Full=Prostaglandin F2-alpha receptor-associated protein; AltName: CD_antigen=CD315; Flags: Precursor;
FUNCTION: Inhibits the binding of prostaglandin F2-alpha (PGF2- alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha receptor seems to occur (By similarity).
SUBUNIT: Interacts with CD9 and CD81. Also seems to interact with CD63, CD82 and CD151.
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type I membrane protein (By similarity). Golgi apparatus, trans- Golgi network membrane; Single-pass type I membrane protein (By similarity).
SIMILARITY: Contains 6 Ig-like C2-type (immunoglobulin-like) domains.
SEQUENCE CAUTION: Sequence=BAA92674.1; Type=Erroneous initiation; Sequence=BAC11104.1; Type=Erroneous termination; Positions=864; Note=Translated as Gln;

-  Primer design for this transcript
 

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Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: PTGFRN
Diseases sorted by gene-association score: exudative vitreoretinopathy (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 34.48 RPKM in Colon - Sigmoid
Total median expression: 462.08 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -126.30288-0.439 Picture PostScript Text
3' UTR -1040.003386-0.307 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR003599 - Ig_sub
IPR013106 - Ig_V-set

Pfam Domains:
PF07686 - Immunoglobulin V-set domain

ModBase Predicted Comparative 3D Structure on Q9P2B2
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein SequenceProtein Sequence   
AlignmentAlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0034389 lipid particle organization

Cellular Component:
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK074637 - Homo sapiens cDNA FLJ90156 fis, clone HEMBB1002245, highly similar to PROSTAGLANDIN F2-ALPHA RECEPTOR REGULATORY PROTEIN PRECURSOR.
AB037857 - Homo sapiens KIAA1436 mRNA for KIAA1436 protein.
BC152454 - Homo sapiens prostaglandin F2 receptor negative regulator, mRNA (cDNA clone MGC:176708 IMAGE:8862587), complete cds.
BC098142 - Homo sapiens prostaglandin F2 receptor negative regulator, mRNA (cDNA clone IMAGE:40012156), partial cds.
BC139718 - Homo sapiens prostaglandin F2 receptor negative regulator, mRNA (cDNA clone IMAGE:40012155), partial cds.
BC063317 - Homo sapiens cDNA clone IMAGE:30347731, containing frame-shift errors.
BC114520 - Homo sapiens prostaglandin F2 receptor negative regulator, mRNA (cDNA clone IMAGE:40036497), partial cds.
AB384207 - Synthetic construct DNA, clone: pF1KSDA1436, Homo sapiens PTGFRN gene for prostaglandin F2 receptor negative regulator precursor, complete cds, without stop codon, in Flexi system.
BC168364 - Synthetic construct Homo sapiens clone IMAGE:100068260, MGC:195877 prostaglandin F2 receptor negative regulator (PTGFRN) mRNA, encodes complete protein.
JD444522 - Sequence 425546 from Patent EP1572962.
JD071687 - Sequence 52711 from Patent EP1572962.
JD043806 - Sequence 24830 from Patent EP1572962.
JD179988 - Sequence 161012 from Patent EP1572962.
JD462684 - Sequence 443708 from Patent EP1572962.
JD211414 - Sequence 192438 from Patent EP1572962.
JD460736 - Sequence 441760 from Patent EP1572962.
JD106159 - Sequence 87183 from Patent EP1572962.
JD382944 - Sequence 363968 from Patent EP1572962.
JD139006 - Sequence 120030 from Patent EP1572962.
JD129263 - Sequence 110287 from Patent EP1572962.
BC042164 - Homo sapiens cDNA clone IMAGE:4858323, containing frame-shift errors.
AB014734 - Homo sapiens mRNA for SMAP-6, partial cds.
BC022235 - Homo sapiens prostaglandin F2 receptor negative regulator, mRNA (cDNA clone IMAGE:4448037), with apparent retained intron.
JD480124 - Sequence 461148 from Patent EP1572962.
JD501815 - Sequence 482839 from Patent EP1572962.
JD036425 - Sequence 17449 from Patent EP1572962.
JD560845 - Sequence 541869 from Patent EP1572962.
JD438689 - Sequence 419713 from Patent EP1572962.
JD090999 - Sequence 72023 from Patent EP1572962.
JD386726 - Sequence 367750 from Patent EP1572962.
JD462341 - Sequence 443365 from Patent EP1572962.
AK024785 - Homo sapiens cDNA: FLJ21132 fis, clone CAS06362.
JD059329 - Sequence 40353 from Patent EP1572962.
JD116281 - Sequence 97305 from Patent EP1572962.
JD291399 - Sequence 272423 from Patent EP1572962.
JD484601 - Sequence 465625 from Patent EP1572962.
JD115489 - Sequence 96513 from Patent EP1572962.
JD190498 - Sequence 171522 from Patent EP1572962.
JD075256 - Sequence 56280 from Patent EP1572962.
JD523128 - Sequence 504152 from Patent EP1572962.
JD260404 - Sequence 241428 from Patent EP1572962.
JD038268 - Sequence 19292 from Patent EP1572962.
AK001863 - Homo sapiens cDNA FLJ11001 fis, clone PLACE1002815.
JD037239 - Sequence 18263 from Patent EP1572962.
JD278129 - Sequence 259153 from Patent EP1572962.
JD297654 - Sequence 278678 from Patent EP1572962.
JD139237 - Sequence 120261 from Patent EP1572962.
JD173872 - Sequence 154896 from Patent EP1572962.
JD308675 - Sequence 289699 from Patent EP1572962.
JD378546 - Sequence 359570 from Patent EP1572962.
JD091766 - Sequence 72790 from Patent EP1572962.
JD516358 - Sequence 497382 from Patent EP1572962.
JD115696 - Sequence 96720 from Patent EP1572962.
JD516663 - Sequence 497687 from Patent EP1572962.
JD546571 - Sequence 527595 from Patent EP1572962.
JD076948 - Sequence 57972 from Patent EP1572962.
JD440230 - Sequence 421254 from Patent EP1572962.
JD314402 - Sequence 295426 from Patent EP1572962.
JD134064 - Sequence 115088 from Patent EP1572962.
JD545506 - Sequence 526530 from Patent EP1572962.
JD396316 - Sequence 377340 from Patent EP1572962.
JD403190 - Sequence 384214 from Patent EP1572962.
JD429953 - Sequence 410977 from Patent EP1572962.
JD156155 - Sequence 137179 from Patent EP1572962.
JD037988 - Sequence 19012 from Patent EP1572962.
JD067357 - Sequence 48381 from Patent EP1572962.
JD058750 - Sequence 39774 from Patent EP1572962.
JD172582 - Sequence 153606 from Patent EP1572962.
JD348343 - Sequence 329367 from Patent EP1572962.
JD500738 - Sequence 481762 from Patent EP1572962.
JD284841 - Sequence 265865 from Patent EP1572962.
JD262455 - Sequence 243479 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: CD9P1, ENST00000393203.1, ENST00000393203.2, EWIF, FPRP, FPRP_HUMAN, KIAA1436, NM_020440, Q5VVU9, Q8N2K6, Q9P2B2, uc001egv.1, uc001egv.2, uc001egv.3
UCSC ID: ENST00000393203.3
RefSeq Accession: NM_020440
Protein: Q9P2B2 (aka FPRP_HUMAN)
CCDS: CCDS890.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.