Human Gene NIT1 (ENST00000368009.7) from GENCODE V44
Description: Homo sapiens nitrilase 1 (NIT1), transcript variant 1, mRNA. (from RefSeq NM_005600) RefSeq Summary (NM_005600): This gene encodes a member of the nitrilase protein family with homology to bacterial and plant nitrilases, enzymes that cleave nitriles and organic amides to the corresponding carboxylic acids plus ammonia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]. Gencode Transcript: ENST00000368009.7 Gencode Gene: ENSG00000158793.14 Transcript (Including UTRs) Position: hg38 chr1:161,118,105-161,121,194 Size: 3,090 Total Exon Count: 7 Strand: + Coding Region Position: hg38 chr1:161,118,177-161,120,765 Size: 2,589 Coding Exon Count: 7
ID:NIT1_HUMAN DESCRIPTION: RecName: Full=Nitrilase homolog 1; EC=3.5.-.-; FUNCTION: Plays a role in cell growth and apoptosis: loss of expression promotes cell growth and resistance to DNA damage stress. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T-cells. Has apparently no omega-amidase activity such as NIT2 (By similarity). SUBCELLULAR LOCATION: Cytoplasm. Mitochondrion (By similarity). TISSUE SPECIFICITY: Detected in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. MISCELLANEOUS: According to Rosetta Stone theory, the existence of a fusion protein in one genome predicts that the separate polypeptides expressed in other organisms function in the same cellular or biochemical pathway. In Drosophila melanogaster and Caenorhabditis elegans, NitFhit is a fusion protein composed of a C-terminal Fhit domain and a domain related to plant and bacterial nitrilase. SIMILARITY: Belongs to the UPF0012 family. SIMILARITY: Contains 1 CN hydrolase domain. SEQUENCE CAUTION: Sequence=AAH46149.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA. Its C-terminal exon is derived from the last exon of the DEDD gene;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q86X76
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
