ID:PP2BB_HUMAN DESCRIPTION: RecName: Full=Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform; EC=3.1.3.16; AltName: Full=CAM-PRP catalytic subunit; AltName: Full=Calmodulin-dependent calcineurin A subunit beta isoform; FUNCTION: Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein + phosphate. COFACTOR: Binds 1 Fe(3+) ion per subunit (By similarity). COFACTOR: Binds 1 zinc ion per subunit (By similarity). SUBUNIT: Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity. INTERACTION: Q99J34:Irak1 (xeno); NbExp=2; IntAct=EBI-1759540, EBI-6117042; P14316:IRF2; NbExp=2; IntAct=EBI-1759540, EBI-2866589; SIMILARITY: Belongs to the PPP phosphatase family. PP-2B subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P16298
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BioCarta from NCI Cancer Genome Anatomy Project h_fMLPpathway - fMLP induced chemokine gene expression in HMC-1 cells h_mef2dPathway - Role of MEF2D in T-cell Apoptosis h_nfatPathway - NFAT and Hypertrophy of the heart (Transcription in the broken heart) h_ndkDynaminPathway - Endocytotic role of NDK, Phosphins and Dynamin h_tcrPathway - T Cell Receptor Signaling Pathway h_bcrPathway - BCR Signaling Pathway h_calcineurinPathway - Effects of calcineurin in Keratinocyte Differentiation h_pgc1aPathway - Regulation of PGC-1a h_hdacPathway - Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK) h_vipPathway - Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells h_fcer1Pathway - Fc Epsilon Receptor I Signaling in Mast Cells h_gpcrPathway - Signaling Pathway from G-Protein Families h_nos1Pathway - Nitric Oxide Signaling Pathway
Reactome (by CSHL, EBI, and GO)
Protein P16298 (Reactome details) participates in the following event(s):
US Server
