Human Gene IFITM3 (ENST00000399808.5) from GENCODE V44
Description: Homo sapiens interferon induced transmembrane protein 3 (IFITM3), transcript variant 2, non-coding RNA. (from RefSeq NR_049759) RefSeq Summary (NM_021034): The protein encoded by this gene is an interferon-induced membrane protein that helps confer immunity to influenza A H1N1 virus, West Nile virus, and dengue virus. Two transcript variants, only one of them protein-coding, have been found for this gene. Another variant encoding an N-terminally truncated isoform has been reported, but the full-length nature of this variant has not been determined. [provided by RefSeq, May 2012]. Gencode Transcript: ENST00000399808.5 Gencode Gene: ENSG00000142089.17 Transcript (Including UTRs) Position: hg38 chr11:319,676-320,860 Size: 1,185 Total Exon Count: 2 Strand: - Coding Region Position: hg38 chr11:319,838-320,813 Size: 976 Coding Exon Count: 2
ID:IFM3_HUMAN DESCRIPTION: RecName: Full=Interferon-induced transmembrane protein 3; AltName: Full=Dispanin subfamily A member 2b; Short=DSPA2b; AltName: Full=Interferon-inducible protein 1-8U; FUNCTION: IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein- mediated viral entry. Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state. SUBUNIT: Interacts with SPP1; the interaction reduces OPN expression. Interacts with ATP6V0B and CD81 (By similarity). SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein. Late endosome membrane; Single-pass type II membrane protein. Lysosome membrane; Single-pass type II membrane protein. INDUCTION: By IFN-alpha and IFNG/IFN-gamma. PTM: Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity against influenza virus. PTM: Not glycosylated. PTM: Polyubiquitinated with both 'Lys-48' and 'Lys-63' linkages. Ubiqutination negatively regulates antiviral activity. Lys-24 is the most prevalent ubiquitination site. POLYMORPHISM: Genetic variations in IFITM3 are responsible for susceptibility to severe influenza virus infection [MIM:614680]. SIMILARITY: Belongs to the CD225/Dispanin family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF04505 - Interferon-induced transmembrane protein
ModBase Predicted Comparative 3D Structure on Q01628
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0002376 immune system process GO:0006955 immune response GO:0009607 response to biotic stimulus GO:0009615 response to virus GO:0032897 negative regulation of viral transcription GO:0034341 response to interferon-gamma GO:0035455 response to interferon-alpha GO:0035456 response to interferon-beta GO:0045071 negative regulation of viral genome replication GO:0045087 innate immune response GO:0046597 negative regulation of viral entry into host cell GO:0051607 defense response to virus GO:0060337 type I interferon signaling pathway
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