Human Gene HBE1 (ENST00000380237.5) from GENCODE V44
Description: The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin. (from UniProt P02100) RefSeq Summary (NM_005330): The epsilon globin gene (HBE) is normally expressed in the embryonic yolk sac: two epsilon chains together with two zeta chains (an alpha-like globin) constitute the embryonic hemoglobin Hb Gower I; two epsilon chains together with two alpha chains form the embryonic Hb Gower II. Both of these embryonic hemoglobins are normally supplanted by fetal, and later, adult hemoglobin. The five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5'-epsilon - G-gamma - A-gamma - delta - beta-3' [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000380237.5 Gencode Gene: ENSG00000213931.7 Transcript (Including UTRs) Position: hg38 chr11:5,268,345-5,505,604 Size: 237,260 Total Exon Count: 5 Strand: - Coding Region Position: hg38 chr11:5,268,469-5,269,890 Size: 1,422 Coding Exon Count: 3
ID:HBE_HUMAN DESCRIPTION: RecName: Full=Hemoglobin subunit epsilon; AltName: Full=Epsilon-globin; AltName: Full=Hemoglobin epsilon chain; FUNCTION: The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin. SUBUNIT: Heterotetramer of two alpha chains and two epsilon chains in early embryonic hemoglobin Gower-2; two zeta chains and two epsilon chains in early embryonic hemoglobin Gower-1. TISSUE SPECIFICITY: Red blood cells. SIMILARITY: Belongs to the globin family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P02100
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.