Human Gene DENND2B (ENST00000534127.5) from GENCODE V44
Description: Homo sapiens DENN domain containing 2B (DENND2B), transcript variant 1, mRNA. (from RefSeq NM_005418) RefSeq Summary (NM_005418): This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000534127.5 Gencode Gene: ENSG00000166444.19 Transcript (Including UTRs) Position: hg38 chr11:8,693,351-8,910,951 Size: 217,601 Total Exon Count: 23 Strand: - Coding Region Position: hg38 chr11:8,694,096-8,750,700 Size: 56,605 Coding Exon Count: 19
ID:ST5_HUMAN DESCRIPTION: RecName: Full=Suppression of tumorigenicity 5 protein; AltName: Full=DENN domain-containing protein 2B; AltName: Full=HeLa tumor suppression 1; FUNCTION: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form. May be involved in cytoskeletal organization and tumorogenicity. Isoform 1 seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Isoform 3 may block ERK2 activation stimulated by ABL1. Isoform 3 may alter cell morphology and cell growth. SUBUNIT: Isoform 1 interacts with the SH3 domain of ABL1. TISSUE SPECIFICITY: Widely expressed with the exception of peripheral blood lymphocytes. Isoform 1 is expressed in several epithelial and fibroblast (including tumorigenic) but absent in lymphoid cell lines (at protein level). Isoform 3 is expressed in primary cell or weakly tumorigenic but not in tumorigenic cell lines (at protein level). SIMILARITY: Contains 1 dDENN domain. SIMILARITY: Contains 1 DENN domain. SIMILARITY: Contains 1 uDENN domain. SEQUENCE CAUTION: Sequence=AAC50925.1; Type=Frameshift; Positions=159, 169;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P78524
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
